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Prognostic performance of serum YKL-40 for one-year clinical outcomes in acute ischemic stroke
Background: Effects of YKL-40 on one-year clinical outcomes including poor clinical outcome, all-cause mortality, and stroke recurrence among acute ischemic stroke (AIS) patients remained elusive. The purpose of this study was to explore the association between serum YKL-40 at admission and one-year...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10008488/ https://www.ncbi.nlm.nih.gov/pubmed/36880855 http://dx.doi.org/10.18632/aging.204553 |
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author | Shi, Guomei Li, Minghao E, Yan Wang, Meng Gong, Pengyu Wang, Xiaorong Lu, Jingye Wu, Weixiang Xue, Shouru Zhou, Junshan Zhou, Rujuan |
author_facet | Shi, Guomei Li, Minghao E, Yan Wang, Meng Gong, Pengyu Wang, Xiaorong Lu, Jingye Wu, Weixiang Xue, Shouru Zhou, Junshan Zhou, Rujuan |
author_sort | Shi, Guomei |
collection | PubMed |
description | Background: Effects of YKL-40 on one-year clinical outcomes including poor clinical outcome, all-cause mortality, and stroke recurrence among acute ischemic stroke (AIS) patients remained elusive. The purpose of this study was to explore the association between serum YKL-40 at admission and one-year clinical outcomes in AIS patients. Methods: In this prospective cohort study, a total of 1002 participants out of 1361 AIS patients from two centers were included for current analysis. Serum YKL-40 concentrations were measured via enzyme-linked immunosorbent assay. Multivariable logistic or Cox regression were performed to explore the independent association of YKL-40 with one-year clinical outcomes, including poor outcome (modified Rankin Scale of 3-6), all-cause mortality, and recurrent stroke. C-statistic, net reclassification index (NRI) and integrated discrimination improvement (IDI) were calculated to evaluate the discriminatory and predictive power of YKL-40 when added to conventional model. Results: Compared with the first quartile of YKL-40, the adjusted odds ratios or hazard ratios with 95% confidence intervals of the fourth quartile were 3.032 (1.627-5.650) for poor outcome, 2.886 (1.320-6.308) for all-cause mortality and 1.694 (0.906-3.169) for recurrent stroke. The addition of serum YKL-40 to conventional model significantly improved reclassification for poor outcome (NRI 0.053, P = 0.031; IDI 0.018, P = 0.001) and all-cause mortality (NRI 0.162, P = 0.036). Conclusions: Elevated serum YKL-40 at admission might be independently associated with one-year poor outcome and all-cause mortality but not stroke recurrence among Chinese AIS patients. |
format | Online Article Text |
id | pubmed-10008488 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Impact Journals |
record_format | MEDLINE/PubMed |
spelling | pubmed-100084882023-03-13 Prognostic performance of serum YKL-40 for one-year clinical outcomes in acute ischemic stroke Shi, Guomei Li, Minghao E, Yan Wang, Meng Gong, Pengyu Wang, Xiaorong Lu, Jingye Wu, Weixiang Xue, Shouru Zhou, Junshan Zhou, Rujuan Aging (Albany NY) Research Paper Background: Effects of YKL-40 on one-year clinical outcomes including poor clinical outcome, all-cause mortality, and stroke recurrence among acute ischemic stroke (AIS) patients remained elusive. The purpose of this study was to explore the association between serum YKL-40 at admission and one-year clinical outcomes in AIS patients. Methods: In this prospective cohort study, a total of 1002 participants out of 1361 AIS patients from two centers were included for current analysis. Serum YKL-40 concentrations were measured via enzyme-linked immunosorbent assay. Multivariable logistic or Cox regression were performed to explore the independent association of YKL-40 with one-year clinical outcomes, including poor outcome (modified Rankin Scale of 3-6), all-cause mortality, and recurrent stroke. C-statistic, net reclassification index (NRI) and integrated discrimination improvement (IDI) were calculated to evaluate the discriminatory and predictive power of YKL-40 when added to conventional model. Results: Compared with the first quartile of YKL-40, the adjusted odds ratios or hazard ratios with 95% confidence intervals of the fourth quartile were 3.032 (1.627-5.650) for poor outcome, 2.886 (1.320-6.308) for all-cause mortality and 1.694 (0.906-3.169) for recurrent stroke. The addition of serum YKL-40 to conventional model significantly improved reclassification for poor outcome (NRI 0.053, P = 0.031; IDI 0.018, P = 0.001) and all-cause mortality (NRI 0.162, P = 0.036). Conclusions: Elevated serum YKL-40 at admission might be independently associated with one-year poor outcome and all-cause mortality but not stroke recurrence among Chinese AIS patients. Impact Journals 2023-02-25 /pmc/articles/PMC10008488/ /pubmed/36880855 http://dx.doi.org/10.18632/aging.204553 Text en Copyright: © 2023 Shi et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Shi, Guomei Li, Minghao E, Yan Wang, Meng Gong, Pengyu Wang, Xiaorong Lu, Jingye Wu, Weixiang Xue, Shouru Zhou, Junshan Zhou, Rujuan Prognostic performance of serum YKL-40 for one-year clinical outcomes in acute ischemic stroke |
title | Prognostic performance of serum YKL-40 for one-year clinical outcomes in acute ischemic stroke |
title_full | Prognostic performance of serum YKL-40 for one-year clinical outcomes in acute ischemic stroke |
title_fullStr | Prognostic performance of serum YKL-40 for one-year clinical outcomes in acute ischemic stroke |
title_full_unstemmed | Prognostic performance of serum YKL-40 for one-year clinical outcomes in acute ischemic stroke |
title_short | Prognostic performance of serum YKL-40 for one-year clinical outcomes in acute ischemic stroke |
title_sort | prognostic performance of serum ykl-40 for one-year clinical outcomes in acute ischemic stroke |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10008488/ https://www.ncbi.nlm.nih.gov/pubmed/36880855 http://dx.doi.org/10.18632/aging.204553 |
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