Cargando…

Isoform-specific effects of neuronal repression of the AMPK catalytic subunit on cognitive function in aged mice

AMP-activated protein kinase (AMPK) functions as a molecular sensor that plays a critical role in maintaining cellular energy homeostasis. Dysregulation of the AMPK signaling has been linked to synaptic failure and cognitive impairments. Our recent study demonstrates abnormally increased AMPK activi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhou, Xueyan, Yang, Wenzhong, Wang, Xin, Ma, Tao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals 2023
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10008489/ https://www.ncbi.nlm.nih.gov/pubmed/36842095 http://dx.doi.org/10.18632/aging.204554

Ejemplares similares

Effect of different γ-subunit isoforms on the regulation of AMPK
por: Willows, Robin, et al.
Publicado: (2017)

Memory Decline and Behavioral Inflexibility in Aged Mice Are Correlated With Dysregulation of Protein Synthesis Capacity
por: Yang, Wenzhong, et al.
Publicado: (2019)

Differential regulation by AMP and ADP of AMPK complexes containing different γ subunit isoforms
por: Ross, Fiona A., et al.
Publicado: (2016)

Evolution of the cAMP-dependent protein kinase (PKA) catalytic subunit isoforms
por: Søberg, Kristoffer, et al.
Publicado: (2017)

PKA regulation of neuronal function requires the dissociation of catalytic subunits from regulatory subunits
por: Xiong, Wei-Hong, et al.
Publicado: (2023)

AMPK Regulates Circadian Rhythms in a Tissue- and Isoform-Specific Manner
por: Um, Jee-Hyun, et al.
Publicado: (2011)

The Puzzling Role of Neuron-Specific PMCA Isoforms in the Aging Process
por: Boczek, Tomasz, et al.
Publicado: (2019)

AMPK potentiation by LKB1 isoforms
por: Thibert, Chantal, et al.
Publicado: (2015)

Neuron-specific regulation of class I PI3K catalytic subunits and their dysfunction in brain disorders
por: Gross, Christina, et al.
Publicado: (2014)

Region‐ and neuronal‐subtype‐specific expression of Na,K‐ATPase alpha and beta subunit isoforms in the mouse brain
por: Murata, Koshi, et al.
Publicado: (2020)

Susceptibility to ATP depletion of primary proximal tubular cell cultures derived from mice lacking either the α1 or the α2 isoform of the catalytic domain of AMPK
por: Lieberthal, Wilfred, et al.
Publicado: (2013)

AMPK agonist AICAR improves cognition and motor coordination in young and aged mice
por: Kobilo, Tali, et al.
Publicado: (2014)

PAF-AH Catalytic Subunits Modulate the Wnt Pathway in Developing GABAergic Neurons
por: Livnat, Idit, et al.
Publicado: (2010)

mRNA for N-Bak, a neuron-specific BH3-only splice isoform of Bak, escapes nonsense-mediated decay and is translationally repressed in the neurons
por: Jakobson, M, et al.
Publicado: (2012)

Simultaneous Ablation of the Catalytic AMPK α-Subunit SNF1 and Mitochondrial Matrix Protease CLPP Results in Pronounced Lifespan Extension
por: Heinz, Daniela, et al.
Publicado: (2021)

The Molecular Basis for Specificity at the Level of the Protein Kinase a Catalytic Subunit
por: Søberg, Kristoffer, et al.
Publicado: (2018)

Opposing Roles for the α Isoform of the Catalytic Subunit of Protein Phosphatase 1 in Inside–Out and Outside–In Integrin Signaling in Murine Platelets
por: Khatlani, Tanvir, et al.
Publicado: (2023)

Naa20, the catalytic subunit of NatB complex, contributes to hepatocellular carcinoma by regulating the LKB1–AMPK–mTOR axis
por: Jung, Taek-Yeol, et al.
Publicado: (2020)

Functional specification of CCK+ interneurons by alternative isoforms of Kv4.3 auxiliary subunits
por: Oláh, Viktor János, et al.
Publicado: (2020)

Human V-ATPase a-subunit isoforms bind specifically to distinct phosphoinositide phospholipids
por: Mitra, Connie, et al.
Publicado: (2023)

Arginine Reduces Glycation in γ(2) Subunit of AMPK and Pathologies in Alzheimer’s Disease Model Mice
por: Zhu, Rui, et al.
Publicado: (2022)

Myeloid-Specific Deletion of the AMPKα2 Subunit Alters Monocyte Protein Expression and Atherogenesis
por: Fisslthaler, Beate, et al.
Publicado: (2019)

Localisation of AMPK γ subunits in cardiac and skeletal muscles
por: Pinter, Katalin, et al.
Publicado: (2013)

Integrative Analysis of the AMPK subunits in Colorectal Adeno Carcinoma
por: T B, Beena, et al.
Publicado: (2023)

Epe1 contributes to activation of AMPK by promoting phosphorylation of AMPK alpha subunit, Ssp2
por: Chen, Yongyi, et al.
Publicado: (2017)

Molecular Cloning, Structural Analysis and Tissue Expression of Protein Phosphatase 3 Catalytic Subunit Alpha Isoform (PPP3CA) Gene in Tianfu Goat Muscle
por: Wan, Lu, et al.
Publicado: (2014)

Isoform-specific AMPK association with TBC1D1 is reduced by a mutation associated with severe obesity
por: Thomas, Elaine C., et al.
Publicado: (2018)

Investigation of Isoform Specific Functions of the V-ATPase a Subunit During Drosophila Wing Development
por: Mo, Dongqing, et al.
Publicado: (2020)

Transcriptional repression induces a slowly progressive atypical neuronal death associated with changes of YAP isoforms and p73
por: Hoshino, Masataka, et al.
Publicado: (2006)

Managing Brain Extracellular K(+) during Neuronal Activity: The Physiological Role of the Na(+)/K(+)-ATPase Subunit Isoforms
por: Larsen, Brian Roland, et al.
Publicado: (2016)

Glucagon-Like Peptide-1 Cleavage Product Improves Cognitive Function in a Mouse Model of Down Syndrome
por: Day, Stephen M., et al.
Publicado: (2019)

The role of phosphoprotein phosphatases catalytic subunit genes in pancreatic cancer
por: Hang, Junjie, et al.
Publicado: (2021)

Differential expression of DNA-dependent protein kinase catalytic subunit in the brain of neonatal mice and young adult mice
por: OKAWA, Aoi, et al.
Publicado: (2020)

FAM13A Represses AMPK Activity and Regulates Hepatic Glucose and Lipid Metabolism
por: Lin, Xin, et al.
Publicado: (2020)

Tissue- and Condition-Specific Isoforms of Mammalian Cytochrome c Oxidase Subunits: From Function to Human Disease
por: Sinkler, Christopher A., et al.
Publicado: (2017)

Specific deletion of protein phosphatase 6 catalytic subunit in Sertoli cells leads to disruption of spermatogenesis
por: Lei, Wen-Long, et al.
Publicado: (2021)

Repressing phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma by microRNA-142-3p restrains the progression of hepatocellular carcinoma
por: Zeng, Chuanli, et al.
Publicado: (2022)

IL-17RC is critically required to maintain baseline A20 production to repress JNK isoform-dependent tumor-specific proliferation
por: Yan, Chi, et al.
Publicado: (2017)

AMPK suppresses Th2 cell responses by repressing mTORC2
por: Pandit, Mahesh, et al.
Publicado: (2022)

Modulation of the Na,K-pump function by beta subunit isoforms
Publicado: (1994)

Cannot write session to /tmp/vufind_sessions/sess_idmlgsnc1pl6u004h31hkmr7n1