Overexpression of tripartite motif-containing 47 (TRIM47) confers sensitivity to PARP inhibition via ubiquitylation of BRCA1 in triple negative breast cancer cells

Triple-negative breast cancers (TNBC) frequently harbor defects in DNA double-strand break repair through homologous recombination (HR), such as BRCA1 dysfunction. However, less than 15% of TNBC patients were found to carry BRCA1 mutation, indicating that there are other mechanisms regulating BRCA1-...

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Detalles Bibliográficos
Autores principales: Liu, Fengen, Xie, Binhui, Ye, Rong, Xie, Yuankang, Zhong, Baiyin, Zhu, Jinrong, Tang, Yao, Lin, Zelong, Tang, Huiru, Wu, Ziqing, Li, Heping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10008536/
https://www.ncbi.nlm.nih.gov/pubmed/36906594
http://dx.doi.org/10.1038/s41389-023-00453-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10008536/
https://www.ncbi.nlm.nih.gov/pubmed/36906594
http://dx.doi.org/10.1038/s41389-023-00453-7

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