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Human parasagittal dura is a potential neuroimmune interface
Parasagittal dura (PSD) is located on both sides of the superior sagittal sinus and harbours arachnoid granulations and lymphatic vessels. Efflux of cerebrospinal fluid (CSF) to human PSD has recently been shown in vivo. Here we obtain PSD volumes from magnetic resonance images in 76 patients under...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10008553/ https://www.ncbi.nlm.nih.gov/pubmed/36906686 http://dx.doi.org/10.1038/s42003-023-04634-3 |
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author | Melin, Erik Ringstad, Geir Valnes, Lars Magnus Eide, Per Kristian |
author_facet | Melin, Erik Ringstad, Geir Valnes, Lars Magnus Eide, Per Kristian |
author_sort | Melin, Erik |
collection | PubMed |
description | Parasagittal dura (PSD) is located on both sides of the superior sagittal sinus and harbours arachnoid granulations and lymphatic vessels. Efflux of cerebrospinal fluid (CSF) to human PSD has recently been shown in vivo. Here we obtain PSD volumes from magnetic resonance images in 76 patients under evaluation for CSF disorders and correlate them to age, sex, intracranial volumes, disease category, sleep quality, and intracranial pressure. In two subgroups, we also analyze tracer dynamics and time to peak tracer level in PSD and blood. PSD volume is not explained by any single assessed variable, but tracer level in PSD is strongly associated with tracer in CSF and brain. Furthermore, peak tracer in PSD occurs far later than peak tracer in blood, implying that PSD is no major efflux route for CSF. These observations may indicate that PSD is more relevant as a neuroimmune interface than as a CSF efflux route. |
format | Online Article Text |
id | pubmed-10008553 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-100085532023-03-13 Human parasagittal dura is a potential neuroimmune interface Melin, Erik Ringstad, Geir Valnes, Lars Magnus Eide, Per Kristian Commun Biol Article Parasagittal dura (PSD) is located on both sides of the superior sagittal sinus and harbours arachnoid granulations and lymphatic vessels. Efflux of cerebrospinal fluid (CSF) to human PSD has recently been shown in vivo. Here we obtain PSD volumes from magnetic resonance images in 76 patients under evaluation for CSF disorders and correlate them to age, sex, intracranial volumes, disease category, sleep quality, and intracranial pressure. In two subgroups, we also analyze tracer dynamics and time to peak tracer level in PSD and blood. PSD volume is not explained by any single assessed variable, but tracer level in PSD is strongly associated with tracer in CSF and brain. Furthermore, peak tracer in PSD occurs far later than peak tracer in blood, implying that PSD is no major efflux route for CSF. These observations may indicate that PSD is more relevant as a neuroimmune interface than as a CSF efflux route. Nature Publishing Group UK 2023-03-11 /pmc/articles/PMC10008553/ /pubmed/36906686 http://dx.doi.org/10.1038/s42003-023-04634-3 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Melin, Erik Ringstad, Geir Valnes, Lars Magnus Eide, Per Kristian Human parasagittal dura is a potential neuroimmune interface |
title | Human parasagittal dura is a potential neuroimmune interface |
title_full | Human parasagittal dura is a potential neuroimmune interface |
title_fullStr | Human parasagittal dura is a potential neuroimmune interface |
title_full_unstemmed | Human parasagittal dura is a potential neuroimmune interface |
title_short | Human parasagittal dura is a potential neuroimmune interface |
title_sort | human parasagittal dura is a potential neuroimmune interface |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10008553/ https://www.ncbi.nlm.nih.gov/pubmed/36906686 http://dx.doi.org/10.1038/s42003-023-04634-3 |
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