Hypomorphic Brca2 and Rad51c double mutant mice display Fanconi anemia, cancer and polygenic replication stress

The prototypic cancer-predisposition disease Fanconi Anemia (FA) is identified by biallelic mutations in any one of twenty-three FANC genes. Puzzlingly, inactivation of one Fanc gene alone in mice fails to faithfully model the pleiotropic human disease without additional external stress. Here we fin...

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Detalles Bibliográficos
Autores principales: Tomaszowski, Karl-Heinz, Roy, Sunetra, Guerrero, Carolina, Shukla, Poojan, Keshvani, Caezaan, Chen, Yue, Ott, Martina, Wu, Xiaogang, Zhang, Jianhua, DiNardo, Courtney D., Schindler, Detlev, Schlacher, Katharina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10008622/
https://www.ncbi.nlm.nih.gov/pubmed/36906610
http://dx.doi.org/10.1038/s41467-023-36933-y

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