Short-term molecular consequences of chromosome mis-segregation for genome stability

Chromosome instability (CIN) is the most common form of genome instability and is a hallmark of cancer. CIN invariably leads to aneuploidy, a state of karyotype imbalance. Here, we show that aneuploidy can also trigger CIN. We found that aneuploid cells experience DNA replication stress in their fir...

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Detalles Bibliográficos
Autores principales: Garribba, Lorenza, De Feudis, Giuseppina, Martis, Valentino, Galli, Martina, Dumont, Marie, Eliezer, Yonatan, Wardenaar, René, Ippolito, Marica Rosaria, Iyer, Divya Ramalingam, Tijhuis, Andréa E., Spierings, Diana C. J., Schubert, Michael, Taglietti, Silvia, Soriani, Chiara, Gemble, Simon, Basto, Renata, Rhind, Nick, Foijer, Floris, Ben-David, Uri, Fachinetti, Daniele, Doksani, Ylli, Santaguida, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10008630/
https://www.ncbi.nlm.nih.gov/pubmed/36906648
http://dx.doi.org/10.1038/s41467-023-37095-7

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