Emerging roles of TFE3 in metabolic regulation

TFE3 is a member of the MiT family of the bHLH-leucine zipper transcription factor. We previously focused on the role of TFE3 in autophagy and cancer. Recently, an increasing number of studies have revealed that TFE3 plays an important role in metabolic regulation. TFE3 participates in the metabolis...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Xingyu, Chen, Yongming, Gong, Siqiao, Chen, Huixia, Liu, Huafeng, Li, Xiaoyu, Hao, Junfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10008649/
https://www.ncbi.nlm.nih.gov/pubmed/36906611
http://dx.doi.org/10.1038/s41420-023-01395-0
_version_ 1784905802582065152
author Li, Xingyu
Chen, Yongming
Gong, Siqiao
Chen, Huixia
Liu, Huafeng
Li, Xiaoyu
Hao, Junfeng
author_facet Li, Xingyu
Chen, Yongming
Gong, Siqiao
Chen, Huixia
Liu, Huafeng
Li, Xiaoyu
Hao, Junfeng
author_sort Li, Xingyu
collection PubMed
description TFE3 is a member of the MiT family of the bHLH-leucine zipper transcription factor. We previously focused on the role of TFE3 in autophagy and cancer. Recently, an increasing number of studies have revealed that TFE3 plays an important role in metabolic regulation. TFE3 participates in the metabolism of energy in the body by regulating pathways such as glucose and lipid metabolism, mitochondrial metabolism, and autophagy. This review summarizes and discusses the specific regulatory mechanisms of TFE3 in metabolism. We determined both the direct regulation of TFE3 on metabolically active cells, such as hepatocytes and skeletal muscle cells, and the indirect regulation of TFE3 through mitochondrial quality control and the autophagy–lysosome pathway. The role of TFE3 in tumor cell metabolism is also summarized in this review. Understanding the diverse roles of TFE3 in metabolic processes can provide new avenues for the treatment of some metabolism-related disorders.
format Online
Article
Text
id pubmed-10008649
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-100086492023-03-13 Emerging roles of TFE3 in metabolic regulation Li, Xingyu Chen, Yongming Gong, Siqiao Chen, Huixia Liu, Huafeng Li, Xiaoyu Hao, Junfeng Cell Death Discov Review Article TFE3 is a member of the MiT family of the bHLH-leucine zipper transcription factor. We previously focused on the role of TFE3 in autophagy and cancer. Recently, an increasing number of studies have revealed that TFE3 plays an important role in metabolic regulation. TFE3 participates in the metabolism of energy in the body by regulating pathways such as glucose and lipid metabolism, mitochondrial metabolism, and autophagy. This review summarizes and discusses the specific regulatory mechanisms of TFE3 in metabolism. We determined both the direct regulation of TFE3 on metabolically active cells, such as hepatocytes and skeletal muscle cells, and the indirect regulation of TFE3 through mitochondrial quality control and the autophagy–lysosome pathway. The role of TFE3 in tumor cell metabolism is also summarized in this review. Understanding the diverse roles of TFE3 in metabolic processes can provide new avenues for the treatment of some metabolism-related disorders. Nature Publishing Group UK 2023-03-11 /pmc/articles/PMC10008649/ /pubmed/36906611 http://dx.doi.org/10.1038/s41420-023-01395-0 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Li, Xingyu
Chen, Yongming
Gong, Siqiao
Chen, Huixia
Liu, Huafeng
Li, Xiaoyu
Hao, Junfeng
Emerging roles of TFE3 in metabolic regulation
title Emerging roles of TFE3 in metabolic regulation
title_full Emerging roles of TFE3 in metabolic regulation
title_fullStr Emerging roles of TFE3 in metabolic regulation
title_full_unstemmed Emerging roles of TFE3 in metabolic regulation
title_short Emerging roles of TFE3 in metabolic regulation
title_sort emerging roles of tfe3 in metabolic regulation
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10008649/
https://www.ncbi.nlm.nih.gov/pubmed/36906611
http://dx.doi.org/10.1038/s41420-023-01395-0
work_keys_str_mv AT lixingyu emergingrolesoftfe3inmetabolicregulation
AT chenyongming emergingrolesoftfe3inmetabolicregulation
AT gongsiqiao emergingrolesoftfe3inmetabolicregulation
AT chenhuixia emergingrolesoftfe3inmetabolicregulation
AT liuhuafeng emergingrolesoftfe3inmetabolicregulation
AT lixiaoyu emergingrolesoftfe3inmetabolicregulation
AT haojunfeng emergingrolesoftfe3inmetabolicregulation

Ejemplares similares