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Surgical safety analysis and clinical experience sharing of myasthenia gravis patients aged 65 and over

BACKGROUND: To evaluate the surgical safety in myasthenia gravis (MG) patients aged 65 and over. METHODS: A total of 564 patients with MG who underwent surgery in the Department of Thoracic Surgery of Beijing Hospital from November 2011 to March 2022 were included in the study and divided into two g...

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Autores principales: Jiao, Peng, Wu, Fanjuan, Wu, Jiangyu, Sun, Yaoguang, Tian, Wenxin, Yu, Hanbo, Huang, Chuan, Li, Donghang, Wu, Qingjun, Ma, Chao, Tong, Hongfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons Australia, Ltd 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10008675/
https://www.ncbi.nlm.nih.gov/pubmed/36691325
http://dx.doi.org/10.1111/1759-7714.14799
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author Jiao, Peng
Wu, Fanjuan
Wu, Jiangyu
Sun, Yaoguang
Tian, Wenxin
Yu, Hanbo
Huang, Chuan
Li, Donghang
Wu, Qingjun
Ma, Chao
Tong, Hongfeng
author_facet Jiao, Peng
Wu, Fanjuan
Wu, Jiangyu
Sun, Yaoguang
Tian, Wenxin
Yu, Hanbo
Huang, Chuan
Li, Donghang
Wu, Qingjun
Ma, Chao
Tong, Hongfeng
author_sort Jiao, Peng
collection PubMed
description BACKGROUND: To evaluate the surgical safety in myasthenia gravis (MG) patients aged 65 and over. METHODS: A total of 564 patients with MG who underwent surgery in the Department of Thoracic Surgery of Beijing Hospital from November 2011 to March 2022 were included in the study and divided into two groups taking the age of 65 as the boundary. Perioperative data of patients were recorded and statistically analyzed. RESULTS: Compared with young patients, FEV1, FEV1% and MVV in lung function of elderly MG patients were worse (p < 0.001, p < 0.001, p = 0.002). Postoperative drainage time was longer (p < 0.001), combined with more drainage volume (p = 0.002). The American Society of Anesthesiologists (ASA) score of elderly MG patients was higher (p < 0.001). Complications were more likely to occur (p = 0.008) after surgery and Clavien‐Dindo classification (CDC) of postoperative complications was also higher (p = 0.003). Meanwhile, postoperative myasthenic crisis (POMC) was more likely to occur (p = 0.038). Logistic regression showed that lower DLCO% (p = 0.049) was an independent risk factor for postoperative complications. CONCLUSIONS: Surgical indications should be considered in each elderly MG patient on an individual basis. Moreover, most elderly MG patients safely survive the perioperative period and benefit from surgery through individualized consideration.
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spelling pubmed-100086752023-03-14 Surgical safety analysis and clinical experience sharing of myasthenia gravis patients aged 65 and over Jiao, Peng Wu, Fanjuan Wu, Jiangyu Sun, Yaoguang Tian, Wenxin Yu, Hanbo Huang, Chuan Li, Donghang Wu, Qingjun Ma, Chao Tong, Hongfeng Thorac Cancer Original Articles BACKGROUND: To evaluate the surgical safety in myasthenia gravis (MG) patients aged 65 and over. METHODS: A total of 564 patients with MG who underwent surgery in the Department of Thoracic Surgery of Beijing Hospital from November 2011 to March 2022 were included in the study and divided into two groups taking the age of 65 as the boundary. Perioperative data of patients were recorded and statistically analyzed. RESULTS: Compared with young patients, FEV1, FEV1% and MVV in lung function of elderly MG patients were worse (p < 0.001, p < 0.001, p = 0.002). Postoperative drainage time was longer (p < 0.001), combined with more drainage volume (p = 0.002). The American Society of Anesthesiologists (ASA) score of elderly MG patients was higher (p < 0.001). Complications were more likely to occur (p = 0.008) after surgery and Clavien‐Dindo classification (CDC) of postoperative complications was also higher (p = 0.003). Meanwhile, postoperative myasthenic crisis (POMC) was more likely to occur (p = 0.038). Logistic regression showed that lower DLCO% (p = 0.049) was an independent risk factor for postoperative complications. CONCLUSIONS: Surgical indications should be considered in each elderly MG patient on an individual basis. Moreover, most elderly MG patients safely survive the perioperative period and benefit from surgery through individualized consideration. John Wiley & Sons Australia, Ltd 2023-01-23 /pmc/articles/PMC10008675/ /pubmed/36691325 http://dx.doi.org/10.1111/1759-7714.14799 Text en © 2023 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Articles
Jiao, Peng
Wu, Fanjuan
Wu, Jiangyu
Sun, Yaoguang
Tian, Wenxin
Yu, Hanbo
Huang, Chuan
Li, Donghang
Wu, Qingjun
Ma, Chao
Tong, Hongfeng
Surgical safety analysis and clinical experience sharing of myasthenia gravis patients aged 65 and over
title Surgical safety analysis and clinical experience sharing of myasthenia gravis patients aged 65 and over
title_full Surgical safety analysis and clinical experience sharing of myasthenia gravis patients aged 65 and over
title_fullStr Surgical safety analysis and clinical experience sharing of myasthenia gravis patients aged 65 and over
title_full_unstemmed Surgical safety analysis and clinical experience sharing of myasthenia gravis patients aged 65 and over
title_short Surgical safety analysis and clinical experience sharing of myasthenia gravis patients aged 65 and over
title_sort surgical safety analysis and clinical experience sharing of myasthenia gravis patients aged 65 and over
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10008675/
https://www.ncbi.nlm.nih.gov/pubmed/36691325
http://dx.doi.org/10.1111/1759-7714.14799
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