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The role of gut microbiota in T cell immunity and immune mediated disorders
Gut microbiota was only considered as a commensal organism that aids in digestion, but recent studies revealed that the microbiome play a critical role in both physiological and pathological immune system. The gut microbiome composition is altered by environmental factors such as diet and hygiene, a...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10008692/ https://www.ncbi.nlm.nih.gov/pubmed/36923929 http://dx.doi.org/10.7150/ijbs.79430 |
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author | Shim, Ju A Ryu, Jeong Ha Jo, Yuna Hong, Changwan |
author_facet | Shim, Ju A Ryu, Jeong Ha Jo, Yuna Hong, Changwan |
author_sort | Shim, Ju A |
collection | PubMed |
description | Gut microbiota was only considered as a commensal organism that aids in digestion, but recent studies revealed that the microbiome play a critical role in both physiological and pathological immune system. The gut microbiome composition is altered by environmental factors such as diet and hygiene, and the alteration affects immune cells, especially T cells. Advanced genomic techniques in microbiome research defined that specific microbes regulate T cell responses and the pathogenesis of immune-mediated disorders. Here, we review features of specific microbes-T cell crosstalk and relationship between the microbes and immunopathogenesis of diseases including in cancers, autoimmune disorders and allergic inflammations. We also discuss the limitations of current experimental animal models, cutting-edge developments and current challenges to overcome in the field, and the possibility of considering gut microbiome in the development of new drug. |
format | Online Article Text |
id | pubmed-10008692 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-100086922023-03-14 The role of gut microbiota in T cell immunity and immune mediated disorders Shim, Ju A Ryu, Jeong Ha Jo, Yuna Hong, Changwan Int J Biol Sci Review Gut microbiota was only considered as a commensal organism that aids in digestion, but recent studies revealed that the microbiome play a critical role in both physiological and pathological immune system. The gut microbiome composition is altered by environmental factors such as diet and hygiene, and the alteration affects immune cells, especially T cells. Advanced genomic techniques in microbiome research defined that specific microbes regulate T cell responses and the pathogenesis of immune-mediated disorders. Here, we review features of specific microbes-T cell crosstalk and relationship between the microbes and immunopathogenesis of diseases including in cancers, autoimmune disorders and allergic inflammations. We also discuss the limitations of current experimental animal models, cutting-edge developments and current challenges to overcome in the field, and the possibility of considering gut microbiome in the development of new drug. Ivyspring International Publisher 2023-02-13 /pmc/articles/PMC10008692/ /pubmed/36923929 http://dx.doi.org/10.7150/ijbs.79430 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
spellingShingle | Review Shim, Ju A Ryu, Jeong Ha Jo, Yuna Hong, Changwan The role of gut microbiota in T cell immunity and immune mediated disorders |
title | The role of gut microbiota in T cell immunity and immune mediated disorders |
title_full | The role of gut microbiota in T cell immunity and immune mediated disorders |
title_fullStr | The role of gut microbiota in T cell immunity and immune mediated disorders |
title_full_unstemmed | The role of gut microbiota in T cell immunity and immune mediated disorders |
title_short | The role of gut microbiota in T cell immunity and immune mediated disorders |
title_sort | role of gut microbiota in t cell immunity and immune mediated disorders |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10008692/ https://www.ncbi.nlm.nih.gov/pubmed/36923929 http://dx.doi.org/10.7150/ijbs.79430 |
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