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The role of gut microbiota in T cell immunity and immune mediated disorders

Gut microbiota was only considered as a commensal organism that aids in digestion, but recent studies revealed that the microbiome play a critical role in both physiological and pathological immune system. The gut microbiome composition is altered by environmental factors such as diet and hygiene, a...

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Detalles Bibliográficos
Autores principales: Shim, Ju A, Ryu, Jeong Ha, Jo, Yuna, Hong, Changwan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10008692/
https://www.ncbi.nlm.nih.gov/pubmed/36923929
http://dx.doi.org/10.7150/ijbs.79430
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author Shim, Ju A
Ryu, Jeong Ha
Jo, Yuna
Hong, Changwan
author_facet Shim, Ju A
Ryu, Jeong Ha
Jo, Yuna
Hong, Changwan
author_sort Shim, Ju A
collection PubMed
description Gut microbiota was only considered as a commensal organism that aids in digestion, but recent studies revealed that the microbiome play a critical role in both physiological and pathological immune system. The gut microbiome composition is altered by environmental factors such as diet and hygiene, and the alteration affects immune cells, especially T cells. Advanced genomic techniques in microbiome research defined that specific microbes regulate T cell responses and the pathogenesis of immune-mediated disorders. Here, we review features of specific microbes-T cell crosstalk and relationship between the microbes and immunopathogenesis of diseases including in cancers, autoimmune disorders and allergic inflammations. We also discuss the limitations of current experimental animal models, cutting-edge developments and current challenges to overcome in the field, and the possibility of considering gut microbiome in the development of new drug.
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spelling pubmed-100086922023-03-14 The role of gut microbiota in T cell immunity and immune mediated disorders Shim, Ju A Ryu, Jeong Ha Jo, Yuna Hong, Changwan Int J Biol Sci Review Gut microbiota was only considered as a commensal organism that aids in digestion, but recent studies revealed that the microbiome play a critical role in both physiological and pathological immune system. The gut microbiome composition is altered by environmental factors such as diet and hygiene, and the alteration affects immune cells, especially T cells. Advanced genomic techniques in microbiome research defined that specific microbes regulate T cell responses and the pathogenesis of immune-mediated disorders. Here, we review features of specific microbes-T cell crosstalk and relationship between the microbes and immunopathogenesis of diseases including in cancers, autoimmune disorders and allergic inflammations. We also discuss the limitations of current experimental animal models, cutting-edge developments and current challenges to overcome in the field, and the possibility of considering gut microbiome in the development of new drug. Ivyspring International Publisher 2023-02-13 /pmc/articles/PMC10008692/ /pubmed/36923929 http://dx.doi.org/10.7150/ijbs.79430 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Review
Shim, Ju A
Ryu, Jeong Ha
Jo, Yuna
Hong, Changwan
The role of gut microbiota in T cell immunity and immune mediated disorders
title The role of gut microbiota in T cell immunity and immune mediated disorders
title_full The role of gut microbiota in T cell immunity and immune mediated disorders
title_fullStr The role of gut microbiota in T cell immunity and immune mediated disorders
title_full_unstemmed The role of gut microbiota in T cell immunity and immune mediated disorders
title_short The role of gut microbiota in T cell immunity and immune mediated disorders
title_sort role of gut microbiota in t cell immunity and immune mediated disorders
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10008692/
https://www.ncbi.nlm.nih.gov/pubmed/36923929
http://dx.doi.org/10.7150/ijbs.79430
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