AIM2 promotes renal cell carcinoma progression and sunitinib resistance through FOXO3a-ACSL4 axis-regulated ferroptosis

Renal cell carcinoma (RCC) is a serious threat to people's health due to its rapid progression, and patients easily develop resistance to targeted therapy. The absent in melanoma 2 (AIM2) is a receptor protein that has recently been proposed to play an important role in various diseases. In thi...

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Autores principales: Wang, Qi, Gao, Su, Shou, Yi, Jia, Yujie, Wei, Zhihao, Liu, Yuenan, Shi, Jian, Miao, Daojia, Miao, Qi, Zhao, Chuanyi, Liu, Chenchen, Yang, Hongmei, Xu, Tianbo, Zhang, Xiaoping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10008700/
https://www.ncbi.nlm.nih.gov/pubmed/36923928
http://dx.doi.org/10.7150/ijbs.79853
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author Wang, Qi
Gao, Su
Shou, Yi
Jia, Yujie
Wei, Zhihao
Liu, Yuenan
Shi, Jian
Miao, Daojia
Miao, Qi
Zhao, Chuanyi
Liu, Chenchen
Yang, Hongmei
Xu, Tianbo
Zhang, Xiaoping
author_facet Wang, Qi
Gao, Su
Shou, Yi
Jia, Yujie
Wei, Zhihao
Liu, Yuenan
Shi, Jian
Miao, Daojia
Miao, Qi
Zhao, Chuanyi
Liu, Chenchen
Yang, Hongmei
Xu, Tianbo
Zhang, Xiaoping
author_sort Wang, Qi
collection PubMed
description Renal cell carcinoma (RCC) is a serious threat to people's health due to its rapid progression, and patients easily develop resistance to targeted therapy. The absent in melanoma 2 (AIM2) is a receptor protein that has recently been proposed to play an important role in various diseases. In this study, AIM2 was identified as a new biomarker of RCC and promoted RCC progression and sunitinib resistance in an inflammasome-independent manner. Mechanistically, AIM2 promoted FOXO3a phosphorylation and proteasome degradation, thereby reducing its transcriptional effect on ACSL4 and inhibiting ferroptosis. In summary, AIM2 promoted RCC progression and sunitinib resistance through FOXO3a-ACSL4 axis-regulated ferroptosis, which could provide new ideas and therapeutic targets for RCC diagnosis and treatment.
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spelling pubmed-100087002023-03-14 AIM2 promotes renal cell carcinoma progression and sunitinib resistance through FOXO3a-ACSL4 axis-regulated ferroptosis Wang, Qi Gao, Su Shou, Yi Jia, Yujie Wei, Zhihao Liu, Yuenan Shi, Jian Miao, Daojia Miao, Qi Zhao, Chuanyi Liu, Chenchen Yang, Hongmei Xu, Tianbo Zhang, Xiaoping Int J Biol Sci Research Paper Renal cell carcinoma (RCC) is a serious threat to people's health due to its rapid progression, and patients easily develop resistance to targeted therapy. The absent in melanoma 2 (AIM2) is a receptor protein that has recently been proposed to play an important role in various diseases. In this study, AIM2 was identified as a new biomarker of RCC and promoted RCC progression and sunitinib resistance in an inflammasome-independent manner. Mechanistically, AIM2 promoted FOXO3a phosphorylation and proteasome degradation, thereby reducing its transcriptional effect on ACSL4 and inhibiting ferroptosis. In summary, AIM2 promoted RCC progression and sunitinib resistance through FOXO3a-ACSL4 axis-regulated ferroptosis, which could provide new ideas and therapeutic targets for RCC diagnosis and treatment. Ivyspring International Publisher 2023-02-13 /pmc/articles/PMC10008700/ /pubmed/36923928 http://dx.doi.org/10.7150/ijbs.79853 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Wang, Qi
Gao, Su
Shou, Yi
Jia, Yujie
Wei, Zhihao
Liu, Yuenan
Shi, Jian
Miao, Daojia
Miao, Qi
Zhao, Chuanyi
Liu, Chenchen
Yang, Hongmei
Xu, Tianbo
Zhang, Xiaoping
AIM2 promotes renal cell carcinoma progression and sunitinib resistance through FOXO3a-ACSL4 axis-regulated ferroptosis
title AIM2 promotes renal cell carcinoma progression and sunitinib resistance through FOXO3a-ACSL4 axis-regulated ferroptosis
title_full AIM2 promotes renal cell carcinoma progression and sunitinib resistance through FOXO3a-ACSL4 axis-regulated ferroptosis
title_fullStr AIM2 promotes renal cell carcinoma progression and sunitinib resistance through FOXO3a-ACSL4 axis-regulated ferroptosis
title_full_unstemmed AIM2 promotes renal cell carcinoma progression and sunitinib resistance through FOXO3a-ACSL4 axis-regulated ferroptosis
title_short AIM2 promotes renal cell carcinoma progression and sunitinib resistance through FOXO3a-ACSL4 axis-regulated ferroptosis
title_sort aim2 promotes renal cell carcinoma progression and sunitinib resistance through foxo3a-acsl4 axis-regulated ferroptosis
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10008700/
https://www.ncbi.nlm.nih.gov/pubmed/36923928
http://dx.doi.org/10.7150/ijbs.79853
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