GLSP and GLSP-derived triterpenes attenuate atherosclerosis and aortic calcification by stimulating ABCA1/G1-mediated macrophage cholesterol efflux and inactivating RUNX2-mediated VSMC osteogenesis

Background and Purpose: Atherosclerosis is the main pathophysiological foundation of cardiovascular disease, which was caused by inflammation and lipid metabolism disorder, along with vascular calcification. Aortic calcification leads to reduced plaque stability and eventually causes plaque rupture...

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Detalles Bibliográficos
Autores principales: Zheng, Guobin, Zhao, Yun, Li, Zhenhao, Hua, Yunqing, Zhang, Jing, Miao, Yaodong, Guo, Yang, Li, Lan, Shi, Jia, Dong, Zhengwei, Yang, Shu, Fan, Guanwei, Ma, Chuanrui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10008734/
https://www.ncbi.nlm.nih.gov/pubmed/36923537
http://dx.doi.org/10.7150/thno.80250

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