B cell-derived anti-beta 2 glycoprotein I antibody mediates hyperhomocysteinemia-aggravated hypertensive glomerular lesions by triggering ferroptosis

Hyperhomocysteinemia (HHcy) is a risk factor for chronic kidney diseases (CKDs) that affects about 85% CKD patients. HHcy stimulates B cells to secrete pathological antibodies, although it is unknown whether this pathway mediates kidney injury. In HHcy-treated 2-kidney, 1-clip (2K1C) hypertensive mu...

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Detalles Bibliográficos
Autores principales: Du, Xing, Ma, Xiaolong, Tan, Ying, Shao, Fangyu, Li, Chun, Zhao, Yang, Miao, Yutong, Han, Lulu, Dang, Guohui, Song, Yuwei, Yang, Dongmin, Deng, Zhenling, Wang, Yue, Jiang, Changtao, Kong, Wei, Feng, Juan, Wang, Xian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10008839/
https://www.ncbi.nlm.nih.gov/pubmed/36907919
http://dx.doi.org/10.1038/s41392-023-01313-x

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