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The ventrolateral prefrontal cortex is part of the modular working memory system: A functional neuroanatomical perspective

For many years, the functional role of the ventrolateral Pre-Frontal Cortex (PFC) was associated with executive functions, specifically in the context of non-affective cognitive processes. However, recent research has suggested that the ventrolateral PFC is also involved in the attention system. The...

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Autores principales: Segal, Orin, Elkana, Odelia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10008902/
https://www.ncbi.nlm.nih.gov/pubmed/36923063
http://dx.doi.org/10.3389/fnana.2023.1076095
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author Segal, Orin
Elkana, Odelia
author_facet Segal, Orin
Elkana, Odelia
author_sort Segal, Orin
collection PubMed
description For many years, the functional role of the ventrolateral Pre-Frontal Cortex (PFC) was associated with executive functions, specifically in the context of non-affective cognitive processes. However, recent research has suggested that the ventrolateral PFC is also involved in the attention system. The Ben Shalom model of the functional organization of the prefrontal cortex (2019) posits that the ventrolateral PFC selects perceptual stimuli after integration by the adjacent ventromedial PFC. This article reviews the state-of-the-art findings to better understand the role of the ventrolateral PFC in the selection of perceptual information as grounded in the Ben Shalom model. Numerous studies have reported converging evidence for the selective role of this area. However, most argue that this perceptual selection takes place through the active updating of information values linked to goal-oriented actions. These studies thus view the ventrolateral PFC as part of a system that actively manipulates and changes processed information such as the working memory function, rather than being part of the attention system. In agreement with this view, this review suggests that this area is part of a complex and modular working memory system and illustrates with reference to Diamond’s work on ADD. This working memory system is functionally and anatomically dispersed and includes the dorsolateral PFC, the ACC, the parietal cortex, the basal ganglia, and the cerebellum. Hence, future research should continue to explore the specific neurofunctional roles of these areas in working memory systems, and the connections between the different subareas in this complex array.
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spelling pubmed-100089022023-03-14 The ventrolateral prefrontal cortex is part of the modular working memory system: A functional neuroanatomical perspective Segal, Orin Elkana, Odelia Front Neuroanat Neuroscience For many years, the functional role of the ventrolateral Pre-Frontal Cortex (PFC) was associated with executive functions, specifically in the context of non-affective cognitive processes. However, recent research has suggested that the ventrolateral PFC is also involved in the attention system. The Ben Shalom model of the functional organization of the prefrontal cortex (2019) posits that the ventrolateral PFC selects perceptual stimuli after integration by the adjacent ventromedial PFC. This article reviews the state-of-the-art findings to better understand the role of the ventrolateral PFC in the selection of perceptual information as grounded in the Ben Shalom model. Numerous studies have reported converging evidence for the selective role of this area. However, most argue that this perceptual selection takes place through the active updating of information values linked to goal-oriented actions. These studies thus view the ventrolateral PFC as part of a system that actively manipulates and changes processed information such as the working memory function, rather than being part of the attention system. In agreement with this view, this review suggests that this area is part of a complex and modular working memory system and illustrates with reference to Diamond’s work on ADD. This working memory system is functionally and anatomically dispersed and includes the dorsolateral PFC, the ACC, the parietal cortex, the basal ganglia, and the cerebellum. Hence, future research should continue to explore the specific neurofunctional roles of these areas in working memory systems, and the connections between the different subareas in this complex array. Frontiers Media S.A. 2023-02-27 /pmc/articles/PMC10008902/ /pubmed/36923063 http://dx.doi.org/10.3389/fnana.2023.1076095 Text en Copyright © 2023 Segal and Elkana. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Segal, Orin
Elkana, Odelia
The ventrolateral prefrontal cortex is part of the modular working memory system: A functional neuroanatomical perspective
title The ventrolateral prefrontal cortex is part of the modular working memory system: A functional neuroanatomical perspective
title_full The ventrolateral prefrontal cortex is part of the modular working memory system: A functional neuroanatomical perspective
title_fullStr The ventrolateral prefrontal cortex is part of the modular working memory system: A functional neuroanatomical perspective
title_full_unstemmed The ventrolateral prefrontal cortex is part of the modular working memory system: A functional neuroanatomical perspective
title_short The ventrolateral prefrontal cortex is part of the modular working memory system: A functional neuroanatomical perspective
title_sort ventrolateral prefrontal cortex is part of the modular working memory system: a functional neuroanatomical perspective
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10008902/
https://www.ncbi.nlm.nih.gov/pubmed/36923063
http://dx.doi.org/10.3389/fnana.2023.1076095
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