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Skin infectome of patients with a tick bite history
INTRODUCTION: Ticks are the most important obligate blood-feeding vectors of human pathogens. With the advance of high-throughput sequencing, more and more bacterial community and virome in tick has been reported, which seems to pose a great threat to people. METHODS: A total of 14 skin specimens co...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10008932/ https://www.ncbi.nlm.nih.gov/pubmed/36923591 http://dx.doi.org/10.3389/fcimb.2023.1113992 |
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author | Zhang, Jie Zheng, Yuan-Chun Chu, Yan-Li Cui, Xiao-Ming Wei, Ran Bian, Cai Liu, Hong-Bo Yao, Nan-Nan Jiang, Rui-Ruo Huo, Qiu-Bo Yuan, Ting-Ting Li, Jie Zhao, Lin Li, Lian-Feng Wang, Qian Wei, Wei Zhu, Jin-Guo Chen, Mei-Chao Gao, Yan Wang, Fei Ye, Jin-Ling Song, Ju-Liang Jiang, Jia-Fu Lam, Tommy Tsan-Yuk Ni, Xue-Bing Jia, Na |
author_facet | Zhang, Jie Zheng, Yuan-Chun Chu, Yan-Li Cui, Xiao-Ming Wei, Ran Bian, Cai Liu, Hong-Bo Yao, Nan-Nan Jiang, Rui-Ruo Huo, Qiu-Bo Yuan, Ting-Ting Li, Jie Zhao, Lin Li, Lian-Feng Wang, Qian Wei, Wei Zhu, Jin-Guo Chen, Mei-Chao Gao, Yan Wang, Fei Ye, Jin-Ling Song, Ju-Liang Jiang, Jia-Fu Lam, Tommy Tsan-Yuk Ni, Xue-Bing Jia, Na |
author_sort | Zhang, Jie |
collection | PubMed |
description | INTRODUCTION: Ticks are the most important obligate blood-feeding vectors of human pathogens. With the advance of high-throughput sequencing, more and more bacterial community and virome in tick has been reported, which seems to pose a great threat to people. METHODS: A total of 14 skin specimens collected from tick-bite patients with mild to severe symptoms were analyzed through meta-transcriptomic sequencings. RESULTS: Four bacteria genera were both detected in the skins and ticks, including Pseudomonas, Acinetobacter, Corynebacterium and Propionibacterium, and three tick-associated viruses, Jingmen tick virus (JMTV), Bole tick virus 4 (BLTV4) and Deer tick mononegavirales-like virus (DTMV) were identified in the skin samples. Except of known pathogens such as pathogenic rickettsia, Coxiella burnetii and JMTV, we suggest Roseomonas cervicalis and BLTV4 as potential new agents amplified in the skins and then disseminated into the blood. As early as 1 day after a tick-bite, these pathogens can transmit to skins and at most four ones can co-infect in skins. DISCUSSION: Advances in sequencing technologies have revealed that the diversity of tick microbiome and virome goes far beyond our previous understanding. This report not only identifies three new potential pathogens in humans but also shows that the skin barrier is vital in preventing horizontal transmissions of tick-associated bacteria or virus communities to the host. It is the first research on patients’ skin infectome after a tick bite and demonstrates that more attention should be paid to the cutaneous response to prevent tick-borne illness. |
format | Online Article Text |
id | pubmed-10008932 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-100089322023-03-14 Skin infectome of patients with a tick bite history Zhang, Jie Zheng, Yuan-Chun Chu, Yan-Li Cui, Xiao-Ming Wei, Ran Bian, Cai Liu, Hong-Bo Yao, Nan-Nan Jiang, Rui-Ruo Huo, Qiu-Bo Yuan, Ting-Ting Li, Jie Zhao, Lin Li, Lian-Feng Wang, Qian Wei, Wei Zhu, Jin-Guo Chen, Mei-Chao Gao, Yan Wang, Fei Ye, Jin-Ling Song, Ju-Liang Jiang, Jia-Fu Lam, Tommy Tsan-Yuk Ni, Xue-Bing Jia, Na Front Cell Infect Microbiol Cellular and Infection Microbiology INTRODUCTION: Ticks are the most important obligate blood-feeding vectors of human pathogens. With the advance of high-throughput sequencing, more and more bacterial community and virome in tick has been reported, which seems to pose a great threat to people. METHODS: A total of 14 skin specimens collected from tick-bite patients with mild to severe symptoms were analyzed through meta-transcriptomic sequencings. RESULTS: Four bacteria genera were both detected in the skins and ticks, including Pseudomonas, Acinetobacter, Corynebacterium and Propionibacterium, and three tick-associated viruses, Jingmen tick virus (JMTV), Bole tick virus 4 (BLTV4) and Deer tick mononegavirales-like virus (DTMV) were identified in the skin samples. Except of known pathogens such as pathogenic rickettsia, Coxiella burnetii and JMTV, we suggest Roseomonas cervicalis and BLTV4 as potential new agents amplified in the skins and then disseminated into the blood. As early as 1 day after a tick-bite, these pathogens can transmit to skins and at most four ones can co-infect in skins. DISCUSSION: Advances in sequencing technologies have revealed that the diversity of tick microbiome and virome goes far beyond our previous understanding. This report not only identifies three new potential pathogens in humans but also shows that the skin barrier is vital in preventing horizontal transmissions of tick-associated bacteria or virus communities to the host. It is the first research on patients’ skin infectome after a tick bite and demonstrates that more attention should be paid to the cutaneous response to prevent tick-borne illness. Frontiers Media S.A. 2023-02-27 /pmc/articles/PMC10008932/ /pubmed/36923591 http://dx.doi.org/10.3389/fcimb.2023.1113992 Text en Copyright © 2023 Zhang, Zheng, Chu, Cui, Wei, Bian, Liu, Yao, Jiang, Huo, Yuan, Li, Zhao, Li, Wang, Wei, Zhu, Chen, Gao, Wang, Ye, Song, Jiang, Lam, Ni and Jia https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cellular and Infection Microbiology Zhang, Jie Zheng, Yuan-Chun Chu, Yan-Li Cui, Xiao-Ming Wei, Ran Bian, Cai Liu, Hong-Bo Yao, Nan-Nan Jiang, Rui-Ruo Huo, Qiu-Bo Yuan, Ting-Ting Li, Jie Zhao, Lin Li, Lian-Feng Wang, Qian Wei, Wei Zhu, Jin-Guo Chen, Mei-Chao Gao, Yan Wang, Fei Ye, Jin-Ling Song, Ju-Liang Jiang, Jia-Fu Lam, Tommy Tsan-Yuk Ni, Xue-Bing Jia, Na Skin infectome of patients with a tick bite history |
title | Skin infectome of patients with a tick bite history |
title_full | Skin infectome of patients with a tick bite history |
title_fullStr | Skin infectome of patients with a tick bite history |
title_full_unstemmed | Skin infectome of patients with a tick bite history |
title_short | Skin infectome of patients with a tick bite history |
title_sort | skin infectome of patients with a tick bite history |
topic | Cellular and Infection Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10008932/ https://www.ncbi.nlm.nih.gov/pubmed/36923591 http://dx.doi.org/10.3389/fcimb.2023.1113992 |
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