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Myeloidcells in the immunosuppressive microenvironment in glioblastoma: The characteristics and therapeutic strategies
Glioblastoma (GBM) is the most common and lethal malignant tumor of the central nervous system in adults. Conventional therapies, including surgery, radiotherapy, and chemotherapy, have limited success in ameliorating patient survival. The immunosuppressive tumor microenvironment, which is infiltrat...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10008967/ https://www.ncbi.nlm.nih.gov/pubmed/36923402 http://dx.doi.org/10.3389/fimmu.2023.994698 |
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author | Huang, Boyuan Zhang, Jin Zong, Wenjing Chen, Sisi Zong, Zhitao Zeng, Xiaojun Zhang, Hongbo |
author_facet | Huang, Boyuan Zhang, Jin Zong, Wenjing Chen, Sisi Zong, Zhitao Zeng, Xiaojun Zhang, Hongbo |
author_sort | Huang, Boyuan |
collection | PubMed |
description | Glioblastoma (GBM) is the most common and lethal malignant tumor of the central nervous system in adults. Conventional therapies, including surgery, radiotherapy, and chemotherapy, have limited success in ameliorating patient survival. The immunosuppressive tumor microenvironment, which is infiltrated by a variety of myeloid cells, has been considered a crucial obstacle to current treatment. Recently, immunotherapy, which has achieved great success in hematological malignancies and some solid cancers, has garnered extensive attention for the treatment of GBM. In this review, we will present evidence on the features and functions of different populations of myeloid cells, and on current clinical advances in immunotherapies for glioblastoma. |
format | Online Article Text |
id | pubmed-10008967 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-100089672023-03-14 Myeloidcells in the immunosuppressive microenvironment in glioblastoma: The characteristics and therapeutic strategies Huang, Boyuan Zhang, Jin Zong, Wenjing Chen, Sisi Zong, Zhitao Zeng, Xiaojun Zhang, Hongbo Front Immunol Immunology Glioblastoma (GBM) is the most common and lethal malignant tumor of the central nervous system in adults. Conventional therapies, including surgery, radiotherapy, and chemotherapy, have limited success in ameliorating patient survival. The immunosuppressive tumor microenvironment, which is infiltrated by a variety of myeloid cells, has been considered a crucial obstacle to current treatment. Recently, immunotherapy, which has achieved great success in hematological malignancies and some solid cancers, has garnered extensive attention for the treatment of GBM. In this review, we will present evidence on the features and functions of different populations of myeloid cells, and on current clinical advances in immunotherapies for glioblastoma. Frontiers Media S.A. 2023-02-27 /pmc/articles/PMC10008967/ /pubmed/36923402 http://dx.doi.org/10.3389/fimmu.2023.994698 Text en Copyright © 2023 Huang, Zhang, Zong, Chen, Zong, Zeng and Zhang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Huang, Boyuan Zhang, Jin Zong, Wenjing Chen, Sisi Zong, Zhitao Zeng, Xiaojun Zhang, Hongbo Myeloidcells in the immunosuppressive microenvironment in glioblastoma: The characteristics and therapeutic strategies |
title | Myeloidcells in the immunosuppressive microenvironment in glioblastoma: The characteristics and therapeutic strategies |
title_full | Myeloidcells in the immunosuppressive microenvironment in glioblastoma: The characteristics and therapeutic strategies |
title_fullStr | Myeloidcells in the immunosuppressive microenvironment in glioblastoma: The characteristics and therapeutic strategies |
title_full_unstemmed | Myeloidcells in the immunosuppressive microenvironment in glioblastoma: The characteristics and therapeutic strategies |
title_short | Myeloidcells in the immunosuppressive microenvironment in glioblastoma: The characteristics and therapeutic strategies |
title_sort | myeloidcells in the immunosuppressive microenvironment in glioblastoma: the characteristics and therapeutic strategies |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10008967/ https://www.ncbi.nlm.nih.gov/pubmed/36923402 http://dx.doi.org/10.3389/fimmu.2023.994698 |
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