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Bioengineered MSC-derived exosomes in skin wound repair and regeneration

Refractory skin defects such as pressure ulcers, diabetic ulcers, and vascular ulcers represent a challenge for clinicians and researchers in many aspects. The treatment strategies for wound healing have high cost and limited efficacy. To ease the financial and psychological burden on patients, a mo...

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Autores principales: Zhao, Hanxing, Li, Zhengyong, Wang, Yixi, Zhou, Kai, Li, Hairui, Bi, Siwei, Wang, Yudong, Wu, Wenqing, Huang, Yeqian, Peng, Bo, Tang, Jun, Pan, Bo, Wang, Baoyun, Chen, Zhixing, Zhang, Zhenyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10009159/
https://www.ncbi.nlm.nih.gov/pubmed/36923255
http://dx.doi.org/10.3389/fcell.2023.1029671
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author Zhao, Hanxing
Li, Zhengyong
Wang, Yixi
Zhou, Kai
Li, Hairui
Bi, Siwei
Wang, Yudong
Wu, Wenqing
Huang, Yeqian
Peng, Bo
Tang, Jun
Pan, Bo
Wang, Baoyun
Chen, Zhixing
Zhang, Zhenyu
author_facet Zhao, Hanxing
Li, Zhengyong
Wang, Yixi
Zhou, Kai
Li, Hairui
Bi, Siwei
Wang, Yudong
Wu, Wenqing
Huang, Yeqian
Peng, Bo
Tang, Jun
Pan, Bo
Wang, Baoyun
Chen, Zhixing
Zhang, Zhenyu
author_sort Zhao, Hanxing
collection PubMed
description Refractory skin defects such as pressure ulcers, diabetic ulcers, and vascular ulcers represent a challenge for clinicians and researchers in many aspects. The treatment strategies for wound healing have high cost and limited efficacy. To ease the financial and psychological burden on patients, a more effective therapeutic approach is needed to address the chronic wound. MSC-derived exosomes (MSC-exosomes), the main bioactive extracellular vesicles of the paracrine effect of MSCs, have been proposed as a new potential cell-free approach for wound healing and skin regeneration. The benefits of MSC-exosomes include their ability to promote angiogenesis and cell proliferation, increase collagen production, regulate inflammation, and finally improve tissue regenerative capacity. However, poor targeting and easy removability of MSC-exosomes from the wound are major obstacles to their use in clinical therapy. Thus, the concept of bioengineering technology has been introduced to modify exosomes, enabling higher concentrations and construction of particles of greater stability with specific therapeutic capability. The use of biomaterials to load MSC-exosomes may be a promising strategy to concentrate dose, create the desired therapeutic efficacy, and maintain a sustained release effect. The beneficial role of MSC-exosomes in wound healing is been widely accepted; however, the potential of bioengineering-modified MSC-exosomes remains unclear. In this review, we attempt to summarize the therapeutic applications of modified MSC-exosomes in wound healing and skin regeneration. The challenges and prospects of bioengineered MSC-exosomes are also discussed.
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spelling pubmed-100091592023-03-14 Bioengineered MSC-derived exosomes in skin wound repair and regeneration Zhao, Hanxing Li, Zhengyong Wang, Yixi Zhou, Kai Li, Hairui Bi, Siwei Wang, Yudong Wu, Wenqing Huang, Yeqian Peng, Bo Tang, Jun Pan, Bo Wang, Baoyun Chen, Zhixing Zhang, Zhenyu Front Cell Dev Biol Cell and Developmental Biology Refractory skin defects such as pressure ulcers, diabetic ulcers, and vascular ulcers represent a challenge for clinicians and researchers in many aspects. The treatment strategies for wound healing have high cost and limited efficacy. To ease the financial and psychological burden on patients, a more effective therapeutic approach is needed to address the chronic wound. MSC-derived exosomes (MSC-exosomes), the main bioactive extracellular vesicles of the paracrine effect of MSCs, have been proposed as a new potential cell-free approach for wound healing and skin regeneration. The benefits of MSC-exosomes include their ability to promote angiogenesis and cell proliferation, increase collagen production, regulate inflammation, and finally improve tissue regenerative capacity. However, poor targeting and easy removability of MSC-exosomes from the wound are major obstacles to their use in clinical therapy. Thus, the concept of bioengineering technology has been introduced to modify exosomes, enabling higher concentrations and construction of particles of greater stability with specific therapeutic capability. The use of biomaterials to load MSC-exosomes may be a promising strategy to concentrate dose, create the desired therapeutic efficacy, and maintain a sustained release effect. The beneficial role of MSC-exosomes in wound healing is been widely accepted; however, the potential of bioengineering-modified MSC-exosomes remains unclear. In this review, we attempt to summarize the therapeutic applications of modified MSC-exosomes in wound healing and skin regeneration. The challenges and prospects of bioengineered MSC-exosomes are also discussed. Frontiers Media S.A. 2023-02-27 /pmc/articles/PMC10009159/ /pubmed/36923255 http://dx.doi.org/10.3389/fcell.2023.1029671 Text en Copyright © 2023 Zhao, Li, Wang, Zhou, Li, Bi, Wang, Wu, Huang, Peng, Tang, Pan, Wang, Chen and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Zhao, Hanxing
Li, Zhengyong
Wang, Yixi
Zhou, Kai
Li, Hairui
Bi, Siwei
Wang, Yudong
Wu, Wenqing
Huang, Yeqian
Peng, Bo
Tang, Jun
Pan, Bo
Wang, Baoyun
Chen, Zhixing
Zhang, Zhenyu
Bioengineered MSC-derived exosomes in skin wound repair and regeneration
title Bioengineered MSC-derived exosomes in skin wound repair and regeneration
title_full Bioengineered MSC-derived exosomes in skin wound repair and regeneration
title_fullStr Bioengineered MSC-derived exosomes in skin wound repair and regeneration
title_full_unstemmed Bioengineered MSC-derived exosomes in skin wound repair and regeneration
title_short Bioengineered MSC-derived exosomes in skin wound repair and regeneration
title_sort bioengineered msc-derived exosomes in skin wound repair and regeneration
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10009159/
https://www.ncbi.nlm.nih.gov/pubmed/36923255
http://dx.doi.org/10.3389/fcell.2023.1029671
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