Cargando…
Bioengineered MSC-derived exosomes in skin wound repair and regeneration
Refractory skin defects such as pressure ulcers, diabetic ulcers, and vascular ulcers represent a challenge for clinicians and researchers in many aspects. The treatment strategies for wound healing have high cost and limited efficacy. To ease the financial and psychological burden on patients, a mo...
Autores principales: | , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10009159/ https://www.ncbi.nlm.nih.gov/pubmed/36923255 http://dx.doi.org/10.3389/fcell.2023.1029671 |
_version_ | 1784905918079565824 |
---|---|
author | Zhao, Hanxing Li, Zhengyong Wang, Yixi Zhou, Kai Li, Hairui Bi, Siwei Wang, Yudong Wu, Wenqing Huang, Yeqian Peng, Bo Tang, Jun Pan, Bo Wang, Baoyun Chen, Zhixing Zhang, Zhenyu |
author_facet | Zhao, Hanxing Li, Zhengyong Wang, Yixi Zhou, Kai Li, Hairui Bi, Siwei Wang, Yudong Wu, Wenqing Huang, Yeqian Peng, Bo Tang, Jun Pan, Bo Wang, Baoyun Chen, Zhixing Zhang, Zhenyu |
author_sort | Zhao, Hanxing |
collection | PubMed |
description | Refractory skin defects such as pressure ulcers, diabetic ulcers, and vascular ulcers represent a challenge for clinicians and researchers in many aspects. The treatment strategies for wound healing have high cost and limited efficacy. To ease the financial and psychological burden on patients, a more effective therapeutic approach is needed to address the chronic wound. MSC-derived exosomes (MSC-exosomes), the main bioactive extracellular vesicles of the paracrine effect of MSCs, have been proposed as a new potential cell-free approach for wound healing and skin regeneration. The benefits of MSC-exosomes include their ability to promote angiogenesis and cell proliferation, increase collagen production, regulate inflammation, and finally improve tissue regenerative capacity. However, poor targeting and easy removability of MSC-exosomes from the wound are major obstacles to their use in clinical therapy. Thus, the concept of bioengineering technology has been introduced to modify exosomes, enabling higher concentrations and construction of particles of greater stability with specific therapeutic capability. The use of biomaterials to load MSC-exosomes may be a promising strategy to concentrate dose, create the desired therapeutic efficacy, and maintain a sustained release effect. The beneficial role of MSC-exosomes in wound healing is been widely accepted; however, the potential of bioengineering-modified MSC-exosomes remains unclear. In this review, we attempt to summarize the therapeutic applications of modified MSC-exosomes in wound healing and skin regeneration. The challenges and prospects of bioengineered MSC-exosomes are also discussed. |
format | Online Article Text |
id | pubmed-10009159 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-100091592023-03-14 Bioengineered MSC-derived exosomes in skin wound repair and regeneration Zhao, Hanxing Li, Zhengyong Wang, Yixi Zhou, Kai Li, Hairui Bi, Siwei Wang, Yudong Wu, Wenqing Huang, Yeqian Peng, Bo Tang, Jun Pan, Bo Wang, Baoyun Chen, Zhixing Zhang, Zhenyu Front Cell Dev Biol Cell and Developmental Biology Refractory skin defects such as pressure ulcers, diabetic ulcers, and vascular ulcers represent a challenge for clinicians and researchers in many aspects. The treatment strategies for wound healing have high cost and limited efficacy. To ease the financial and psychological burden on patients, a more effective therapeutic approach is needed to address the chronic wound. MSC-derived exosomes (MSC-exosomes), the main bioactive extracellular vesicles of the paracrine effect of MSCs, have been proposed as a new potential cell-free approach for wound healing and skin regeneration. The benefits of MSC-exosomes include their ability to promote angiogenesis and cell proliferation, increase collagen production, regulate inflammation, and finally improve tissue regenerative capacity. However, poor targeting and easy removability of MSC-exosomes from the wound are major obstacles to their use in clinical therapy. Thus, the concept of bioengineering technology has been introduced to modify exosomes, enabling higher concentrations and construction of particles of greater stability with specific therapeutic capability. The use of biomaterials to load MSC-exosomes may be a promising strategy to concentrate dose, create the desired therapeutic efficacy, and maintain a sustained release effect. The beneficial role of MSC-exosomes in wound healing is been widely accepted; however, the potential of bioengineering-modified MSC-exosomes remains unclear. In this review, we attempt to summarize the therapeutic applications of modified MSC-exosomes in wound healing and skin regeneration. The challenges and prospects of bioengineered MSC-exosomes are also discussed. Frontiers Media S.A. 2023-02-27 /pmc/articles/PMC10009159/ /pubmed/36923255 http://dx.doi.org/10.3389/fcell.2023.1029671 Text en Copyright © 2023 Zhao, Li, Wang, Zhou, Li, Bi, Wang, Wu, Huang, Peng, Tang, Pan, Wang, Chen and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Zhao, Hanxing Li, Zhengyong Wang, Yixi Zhou, Kai Li, Hairui Bi, Siwei Wang, Yudong Wu, Wenqing Huang, Yeqian Peng, Bo Tang, Jun Pan, Bo Wang, Baoyun Chen, Zhixing Zhang, Zhenyu Bioengineered MSC-derived exosomes in skin wound repair and regeneration |
title | Bioengineered MSC-derived exosomes in skin wound repair and regeneration |
title_full | Bioengineered MSC-derived exosomes in skin wound repair and regeneration |
title_fullStr | Bioengineered MSC-derived exosomes in skin wound repair and regeneration |
title_full_unstemmed | Bioengineered MSC-derived exosomes in skin wound repair and regeneration |
title_short | Bioengineered MSC-derived exosomes in skin wound repair and regeneration |
title_sort | bioengineered msc-derived exosomes in skin wound repair and regeneration |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10009159/ https://www.ncbi.nlm.nih.gov/pubmed/36923255 http://dx.doi.org/10.3389/fcell.2023.1029671 |
work_keys_str_mv | AT zhaohanxing bioengineeredmscderivedexosomesinskinwoundrepairandregeneration AT lizhengyong bioengineeredmscderivedexosomesinskinwoundrepairandregeneration AT wangyixi bioengineeredmscderivedexosomesinskinwoundrepairandregeneration AT zhoukai bioengineeredmscderivedexosomesinskinwoundrepairandregeneration AT lihairui bioengineeredmscderivedexosomesinskinwoundrepairandregeneration AT bisiwei bioengineeredmscderivedexosomesinskinwoundrepairandregeneration AT wangyudong bioengineeredmscderivedexosomesinskinwoundrepairandregeneration AT wuwenqing bioengineeredmscderivedexosomesinskinwoundrepairandregeneration AT huangyeqian bioengineeredmscderivedexosomesinskinwoundrepairandregeneration AT pengbo bioengineeredmscderivedexosomesinskinwoundrepairandregeneration AT tangjun bioengineeredmscderivedexosomesinskinwoundrepairandregeneration AT panbo bioengineeredmscderivedexosomesinskinwoundrepairandregeneration AT wangbaoyun bioengineeredmscderivedexosomesinskinwoundrepairandregeneration AT chenzhixing bioengineeredmscderivedexosomesinskinwoundrepairandregeneration AT zhangzhenyu bioengineeredmscderivedexosomesinskinwoundrepairandregeneration |