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Post‐therapy plasma concentrations of quetiapine in Taiwanese patients
AIMS: Quetiapine is widely used to treat psychiatric disorders such as major depression, generalized anxiety disorder, dysthymic disorder, and insomnia other than schizophrenia and bipolar disorder. This study investigated the diagnostic distribution of quetiapine use in patients in a psychiatric ho...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10009434/ https://www.ncbi.nlm.nih.gov/pubmed/36647121 http://dx.doi.org/10.1002/npr2.12303 |
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author | Huang, Cho‐Yin Lin, Yen‐Feng Chen, Chia‐Ru Lin, Shih‐Ku |
author_facet | Huang, Cho‐Yin Lin, Yen‐Feng Chen, Chia‐Ru Lin, Shih‐Ku |
author_sort | Huang, Cho‐Yin |
collection | PubMed |
description | AIMS: Quetiapine is widely used to treat psychiatric disorders such as major depression, generalized anxiety disorder, dysthymic disorder, and insomnia other than schizophrenia and bipolar disorder. This study investigated the diagnostic distribution of quetiapine use in patients in a psychiatric hospital, the doses of quetiapine prescribed, and the plasma concentrations (Cps) of quetiapine and active metabolites. METHODS: We enrolled 107 patients who had been prescribed quetiapine for at least 4 weeks. Diagnoses, demographics, and concomitant medications were recorded. Blood sampling was performed in the morning, approximately 12 h after the before‐bed dose of quetiapine. RESULTS: Diagnoses comprised schizophrenia (n = 25), bipolar disorder (n = 51), major depression (n = 15), dysthymic disorder (n = 9), and others (n = 7). The daily dose (DD) of quetiapine ranged from 25 to 800 (175.9 ± 184.4) mg, with the mean Cp being 105.6 ± 215.3 ng/ml, with a mean Cps/DD ratio of 0.58 ± 0.55 ng/ml/mg. There was a moderate positive linear correlation between the dose and Cps of quetiapine (r = 0.60), and the interpatient variation in Cps/DD ratio was up to 26‐fold. CONCLUSION: Quetiapine is used in various doses to treat many psychiatric disorders other than psychosis, and it is usually prescribed as a secondary antipsychotic for symptoms such as insomnia or agitation. A wide interpatient variation of the Cps/DD ratio was noticed. Patients of East Asian descent may exhibit a 50% to 100% increase in the Cps/DD ratio for quetiapine compared with patients of Western descent. |
format | Online Article Text |
id | pubmed-10009434 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-100094342023-03-14 Post‐therapy plasma concentrations of quetiapine in Taiwanese patients Huang, Cho‐Yin Lin, Yen‐Feng Chen, Chia‐Ru Lin, Shih‐Ku Neuropsychopharmacol Rep Original Articles AIMS: Quetiapine is widely used to treat psychiatric disorders such as major depression, generalized anxiety disorder, dysthymic disorder, and insomnia other than schizophrenia and bipolar disorder. This study investigated the diagnostic distribution of quetiapine use in patients in a psychiatric hospital, the doses of quetiapine prescribed, and the plasma concentrations (Cps) of quetiapine and active metabolites. METHODS: We enrolled 107 patients who had been prescribed quetiapine for at least 4 weeks. Diagnoses, demographics, and concomitant medications were recorded. Blood sampling was performed in the morning, approximately 12 h after the before‐bed dose of quetiapine. RESULTS: Diagnoses comprised schizophrenia (n = 25), bipolar disorder (n = 51), major depression (n = 15), dysthymic disorder (n = 9), and others (n = 7). The daily dose (DD) of quetiapine ranged from 25 to 800 (175.9 ± 184.4) mg, with the mean Cp being 105.6 ± 215.3 ng/ml, with a mean Cps/DD ratio of 0.58 ± 0.55 ng/ml/mg. There was a moderate positive linear correlation between the dose and Cps of quetiapine (r = 0.60), and the interpatient variation in Cps/DD ratio was up to 26‐fold. CONCLUSION: Quetiapine is used in various doses to treat many psychiatric disorders other than psychosis, and it is usually prescribed as a secondary antipsychotic for symptoms such as insomnia or agitation. A wide interpatient variation of the Cps/DD ratio was noticed. Patients of East Asian descent may exhibit a 50% to 100% increase in the Cps/DD ratio for quetiapine compared with patients of Western descent. John Wiley and Sons Inc. 2023-01-16 /pmc/articles/PMC10009434/ /pubmed/36647121 http://dx.doi.org/10.1002/npr2.12303 Text en © 2023 The Authors. Neuropsychopharmacology Reports published by John Wiley & Sons Australia, Ltd on behalf of The Japanese Society of Neuropsychopharmacology. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Original Articles Huang, Cho‐Yin Lin, Yen‐Feng Chen, Chia‐Ru Lin, Shih‐Ku Post‐therapy plasma concentrations of quetiapine in Taiwanese patients |
title | Post‐therapy plasma concentrations of quetiapine in Taiwanese patients |
title_full | Post‐therapy plasma concentrations of quetiapine in Taiwanese patients |
title_fullStr | Post‐therapy plasma concentrations of quetiapine in Taiwanese patients |
title_full_unstemmed | Post‐therapy plasma concentrations of quetiapine in Taiwanese patients |
title_short | Post‐therapy plasma concentrations of quetiapine in Taiwanese patients |
title_sort | post‐therapy plasma concentrations of quetiapine in taiwanese patients |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10009434/ https://www.ncbi.nlm.nih.gov/pubmed/36647121 http://dx.doi.org/10.1002/npr2.12303 |
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