Cargando…

Distinct metabolic features of genetic liability to type 2 diabetes and coronary artery disease: a reverse Mendelian randomization study

BACKGROUND: Type 2 diabetes (T2D) and coronary artery disease (CAD) both have known genetic determinants, but the mechanisms through which their associated genetic variants lead to disease onset remain poorly understood. METHODS: We used large-scale metabolomics data in a two-sample reverse Mendelia...

Descripción completa

Detalles Bibliográficos
Autores principales:	Smith, Madeleine L., Bull, Caroline J., Holmes, Michael V., Davey Smith, George, Sanderson, Eleanor, Anderson, Emma L., Bell, Joshua A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10009453/ https://www.ncbi.nlm.nih.gov/pubmed/36870196 http://dx.doi.org/10.1016/j.ebiom.2023.104503

Ejemplares similares

Identifying metabolic features of colorectal cancer liability using Mendelian randomization
por: Bull, Caroline J., et al.
Publicado: (2023)

Early Metabolic Features of Genetic Liability to Type 2 Diabetes: Cohort Study With Repeated Metabolomics Across Early Life
por: Bell, Joshua A., et al.
Publicado: (2020)

Investigating causality between liability to ADHD and substance use, and liability to substance use and ADHD risk, using Mendelian randomization
por: Treur, Jorien L., et al.
Publicado: (2019)

Is genetic liability to ADHD and ASD causally linked to educational attainment?
por: Dardani, Christina, et al.
Publicado: (2021)

Reappraising the role of instrumental inequalities for mendelian randomization studies in the mega Biobank era
por: Sanderson, Eleanor, et al.
Publicado: (2023)

Multivariable two-sample Mendelian randomization estimates of the effects of intelligence and education on health
por: Davies, Neil Martin, et al.
Publicado: (2019)

Evaluating the relationship between circulating lipoprotein lipids and apolipoproteins with risk of coronary heart disease: A multivariable Mendelian randomisation analysis
por: Richardson, Tom G., et al.
Publicado: (2020)

An examination of multivariable Mendelian randomization in the single-sample and two-sample summary data settings
por: Sanderson, Eleanor, et al.
Publicado: (2019)

Mendelian randomisation analysis of the effect of educational attainment and cognitive ability on smoking behaviour
por: Sanderson, Eleanor, et al.
Publicado: (2019)

The use of negative control outcomes in Mendelian randomization to detect potential population stratification
por: Sanderson, Eleanor, et al.
Publicado: (2021)

Corrigendum to: An examination of multivariable Mendelian randomization in the single-sample and two-sample summary data settings
por: Sanderson, Eleanor, et al.
Publicado: (2020)

A Guide for Understanding and Designing Mendelian Randomization Studies in the Musculoskeletal Field
por: Hartley, April E, et al.
Publicado: (2022)

A phenome-wide bidirectional Mendelian randomization analysis of atrial fibrillation
por: Wang, Qin, et al.
Publicado: (2022)

Interaction-based Mendelian randomization with measured and unmeasured gene-by-covariate interactions
por: Spiller, Wes, et al.
Publicado: (2022)

Exploring the causal effects of genetic liability to ADHD and Autism on Alzheimer’s disease
por: Pagoni, Panagiota, et al.
Publicado: (2022)

Use of genetic variation to separate the effects of early and later life adiposity on disease risk: mendelian randomisation study
por: Richardson, Tom G, et al.
Publicado: (2020)

Estimation of causal effects of a time-varying exposure at multiple time points through multivariable mendelian randomization
por: Sanderson, Eleanor, et al.
Publicado: (2022)

Interpretation of Mendelian randomization using a single measure of an exposure that varies over time
por: Morris, Tim T, et al.
Publicado: (2022)

Mendelian randomization applied to pharmaceutical use: the case of metformin and lung cancer
por: Yarmolinsky, James, et al.
Publicado: (2020)

Effects of general and central adiposity on circulating lipoprotein, lipid, and metabolite levels in UK Biobank: A multivariable Mendelian randomization study
por: Bell, Joshua A., et al.
Publicado: (2022)

Deciphering how early life adiposity influences breast cancer risk using Mendelian randomization
por: Vabistsevits, Marina, et al.
Publicado: (2022)

Genetic liability to insomnia in relation to cardiovascular diseases: a Mendelian randomisation study
por: Yuan, Shuai, et al.
Publicado: (2021)

Genetic Liability to Insomnia and Lung Cancer Risk: A Mendelian Randomization Analysis
por: Shen, Jiayi, et al.
Publicado: (2021)

Genetic liability to obesity and peptic ulcer disease: a Mendelian randomization study
por: Li, Zhoubin, et al.
Publicado: (2022)

Genetic liability to asthma and risk of cardiovascular diseases: A Mendelian randomization study
por: Chen, Heng, et al.
Publicado: (2022)

Influence of puberty timing on adiposity and cardiometabolic traits: A Mendelian randomisation study
por: Bell, Joshua A., et al.
Publicado: (2018)

Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation
por: Richardson, Tom G., et al.
Publicado: (2022)

Exploiting horizontal pleiotropy to search for causal pathways within a Mendelian randomization framework
por: Cho, Yoonsu, et al.
Publicado: (2020)

Mendelian randomisation for mediation analysis: current methods and challenges for implementation
por: Carter, Alice R., et al.
Publicado: (2021)

Education and coronary heart disease: mendelian randomisation study
por: Tillmann, Taavi, et al.
Publicado: (2017)

Education, intelligence and Alzheimer’s disease: evidence from a multivariable two-sample Mendelian randomization study
por: Anderson, Emma L, et al.
Publicado: (2020)

Genetic liability to multiple factors and uterine leiomyoma risk: a Mendelian randomization study
por: Qu, Yangming, et al.
Publicado: (2023)

Nuclear liability
por: Weinstein, Jerry L
Publicado: (1962)

Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians
por: Davies, Neil M, et al.
Publicado: (2018)

Separating the effects of early and later life adiposity on colorectal cancer risk: a Mendelian randomization study
por: Papadimitriou, Nikos, et al.
Publicado: (2023)

Evaluating the effect of metabolic traits on oral and oropharyngeal cancer risk using Mendelian randomization
por: Gormley, Mark, et al.
Publicado: (2023)

Effect of genetic liability to migraine and its subtypes on breast cancer: a mendelian randomization study
por: Fang, Tian, et al.
Publicado: (2023)

Genetic liability to schizophrenia is associated with exposure to traumatic events in childhood
por: Sallis, Hannah M., et al.
Publicado: (2021)

Effects of apolipoprotein B on lifespan and risks of major diseases including type 2 diabetes: a mendelian randomisation analysis using outcomes in first-degree relatives
por: Richardson, Tom G, et al.
Publicado: (2021)

Impact of Liability to Periodontitis on Glycemic Control and Type II Diabetes Risk: A Mendelian Randomization Study
por: Shah, Parth D., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_gpir7bf6oq27fck1hjfs8dcu5u