Development of Selective ADAMTS-5 Peptide Substrates to Monitor Proteinase Activity

[Image: see text] The dysregulation of proteinase activity is a hallmark of osteoarthritis (OA), a disease characterized by progressive degradation of articular cartilage by catabolic proteinases such as a disintegrin and metalloproteinase with thrombospondin type I motifs-5 (ADAMTS-5). The ability...

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Detalles Bibliográficos
Autores principales: Fowkes, Milan M., Troeberg, Linda, Brennan, Paul E., Vincent, Tonia L., Meldal, Morten, Lim, Ngee H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10009750/
https://www.ncbi.nlm.nih.gov/pubmed/36891740
http://dx.doi.org/10.1021/acs.jmedchem.2c02090

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10009750/
https://www.ncbi.nlm.nih.gov/pubmed/36891740
http://dx.doi.org/10.1021/acs.jmedchem.2c02090

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