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Continuous-Flow Technology for Chemical Rearrangements: A Powerful Tool to Generate Pharmaceutically Relevant Compounds
[Image: see text] The efficacy, safety, and scale-up of several chemical rearrangements remain unsolved problems due to the associated handling of hazardous, toxic, and pollutant chemicals and high-risk intermediates. For many years batch processes have been considered the only possibility to drive...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10009796/ https://www.ncbi.nlm.nih.gov/pubmed/36923914 http://dx.doi.org/10.1021/acsmedchemlett.3c00010 |
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author | Alfano, Antonella Ilenia Pelliccia, Sveva Rossino, Giacomo Chianese, Orazio Summa, Vincenzo Collina, Simona Brindisi, Margherita |
author_facet | Alfano, Antonella Ilenia Pelliccia, Sveva Rossino, Giacomo Chianese, Orazio Summa, Vincenzo Collina, Simona Brindisi, Margherita |
author_sort | Alfano, Antonella Ilenia |
collection | PubMed |
description | [Image: see text] The efficacy, safety, and scale-up of several chemical rearrangements remain unsolved problems due to the associated handling of hazardous, toxic, and pollutant chemicals and high-risk intermediates. For many years batch processes have been considered the only possibility to drive these reactions, but continuous-flow technology has emerged, for both academic laboratories and pharmaceutical companies, as a powerful tool for easy, controlled, and safer chemistry protocols, helping to minimize the formation of side products and increase reaction yields. This Technology Note summarizes recently reported chemical rearrangements using continuous-flow approaches, with a focus on Curtius, Hofmann, and Schmidt reactions. Flow protocols, general advantages and safety aspects, and reaction scope for the generation of both privileged scaffolds and active pharmaceutical ingredients will be showcased. |
format | Online Article Text |
id | pubmed-10009796 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-100097962023-03-14 Continuous-Flow Technology for Chemical Rearrangements: A Powerful Tool to Generate Pharmaceutically Relevant Compounds Alfano, Antonella Ilenia Pelliccia, Sveva Rossino, Giacomo Chianese, Orazio Summa, Vincenzo Collina, Simona Brindisi, Margherita ACS Med Chem Lett [Image: see text] The efficacy, safety, and scale-up of several chemical rearrangements remain unsolved problems due to the associated handling of hazardous, toxic, and pollutant chemicals and high-risk intermediates. For many years batch processes have been considered the only possibility to drive these reactions, but continuous-flow technology has emerged, for both academic laboratories and pharmaceutical companies, as a powerful tool for easy, controlled, and safer chemistry protocols, helping to minimize the formation of side products and increase reaction yields. This Technology Note summarizes recently reported chemical rearrangements using continuous-flow approaches, with a focus on Curtius, Hofmann, and Schmidt reactions. Flow protocols, general advantages and safety aspects, and reaction scope for the generation of both privileged scaffolds and active pharmaceutical ingredients will be showcased. American Chemical Society 2023-02-03 /pmc/articles/PMC10009796/ /pubmed/36923914 http://dx.doi.org/10.1021/acsmedchemlett.3c00010 Text en © 2023 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Alfano, Antonella Ilenia Pelliccia, Sveva Rossino, Giacomo Chianese, Orazio Summa, Vincenzo Collina, Simona Brindisi, Margherita Continuous-Flow Technology for Chemical Rearrangements: A Powerful Tool to Generate Pharmaceutically Relevant Compounds |
title | Continuous-Flow Technology for Chemical Rearrangements:
A Powerful Tool to Generate Pharmaceutically Relevant Compounds |
title_full | Continuous-Flow Technology for Chemical Rearrangements:
A Powerful Tool to Generate Pharmaceutically Relevant Compounds |
title_fullStr | Continuous-Flow Technology for Chemical Rearrangements:
A Powerful Tool to Generate Pharmaceutically Relevant Compounds |
title_full_unstemmed | Continuous-Flow Technology for Chemical Rearrangements:
A Powerful Tool to Generate Pharmaceutically Relevant Compounds |
title_short | Continuous-Flow Technology for Chemical Rearrangements:
A Powerful Tool to Generate Pharmaceutically Relevant Compounds |
title_sort | continuous-flow technology for chemical rearrangements:
a powerful tool to generate pharmaceutically relevant compounds |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10009796/ https://www.ncbi.nlm.nih.gov/pubmed/36923914 http://dx.doi.org/10.1021/acsmedchemlett.3c00010 |
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