Eukaryotic Initiation Factor 5A2 localizes to actively translating ribosomes to promote cancer cell protrusions and invasive capacity

BACKGROUND: Eukaryotic Initiation Factor 5A (eIF-5A), an essential translation factor, is post-translationally activated by the polyamine spermidine. Two human genes encode eIF-5A, being eIF5-A1 constitutively expressed whereas eIF5-A2 is frequently found overexpressed in human tumours. The contribu...

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Detalles Bibliográficos
Autores principales: Martínez-Férriz, Arantxa, Gandía, Carolina, Pardo-Sánchez, José Miguel, Fathinajafabadi, Alihamze, Ferrando, Alejandro, Farràs, Rosa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10009989/
https://www.ncbi.nlm.nih.gov/pubmed/36915194
http://dx.doi.org/10.1186/s12964-023-01076-6

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