The emerging role of the piRNA/PIWI complex in respiratory tract diseases

PIWI-interacting RNA (piRNA) is a class of recently discovered small non-coding RNA molecules with a length of 18–33 nt that interacts with the PIWI protein to form the piRNA/PIWI complex. The PIWI family is a subfamily of Argonaute (AGO) proteins that also contain the AGO family which bind to micro...

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Autores principales: Yao, Yizhu, Li, Yaozhe, Zhu, Xiayan, Zhao, Chengguang, Yang, Lehe, Huang, Xiaoying, Wang, Liangxing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10010017/
https://www.ncbi.nlm.nih.gov/pubmed/36915129
http://dx.doi.org/10.1186/s12931-023-02367-9
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author Yao, Yizhu
Li, Yaozhe
Zhu, Xiayan
Zhao, Chengguang
Yang, Lehe
Huang, Xiaoying
Wang, Liangxing
author_facet Yao, Yizhu
Li, Yaozhe
Zhu, Xiayan
Zhao, Chengguang
Yang, Lehe
Huang, Xiaoying
Wang, Liangxing
author_sort Yao, Yizhu
collection PubMed
description PIWI-interacting RNA (piRNA) is a class of recently discovered small non-coding RNA molecules with a length of 18–33 nt that interacts with the PIWI protein to form the piRNA/PIWI complex. The PIWI family is a subfamily of Argonaute (AGO) proteins that also contain the AGO family which bind to microRNA (miRNA). Recently studies indicate that piRNAs are not specific to in the mammalian germline, they are also expressed in a tissue-specific manner in a variety of human tissues and participated in various of diseases, such as cardiovascular, neurological, and urinary tract diseases, and are especially prevalent in malignant tumors in these systems. However, the functions and abnormal expression of piRNAs in respiratory tract diseases and their underlying mechanisms remain incompletely understood. In this review, we discuss current studies summarizing the biogenetic processes, functions, and emerging roles of piRNAs in respiratory tract diseases, providing a reference value for future piRNA research.
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spelling pubmed-100100172023-03-14 The emerging role of the piRNA/PIWI complex in respiratory tract diseases Yao, Yizhu Li, Yaozhe Zhu, Xiayan Zhao, Chengguang Yang, Lehe Huang, Xiaoying Wang, Liangxing Respir Res Review PIWI-interacting RNA (piRNA) is a class of recently discovered small non-coding RNA molecules with a length of 18–33 nt that interacts with the PIWI protein to form the piRNA/PIWI complex. The PIWI family is a subfamily of Argonaute (AGO) proteins that also contain the AGO family which bind to microRNA (miRNA). Recently studies indicate that piRNAs are not specific to in the mammalian germline, they are also expressed in a tissue-specific manner in a variety of human tissues and participated in various of diseases, such as cardiovascular, neurological, and urinary tract diseases, and are especially prevalent in malignant tumors in these systems. However, the functions and abnormal expression of piRNAs in respiratory tract diseases and their underlying mechanisms remain incompletely understood. In this review, we discuss current studies summarizing the biogenetic processes, functions, and emerging roles of piRNAs in respiratory tract diseases, providing a reference value for future piRNA research. BioMed Central 2023-03-13 2023 /pmc/articles/PMC10010017/ /pubmed/36915129 http://dx.doi.org/10.1186/s12931-023-02367-9 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Yao, Yizhu
Li, Yaozhe
Zhu, Xiayan
Zhao, Chengguang
Yang, Lehe
Huang, Xiaoying
Wang, Liangxing
The emerging role of the piRNA/PIWI complex in respiratory tract diseases
title The emerging role of the piRNA/PIWI complex in respiratory tract diseases
title_full The emerging role of the piRNA/PIWI complex in respiratory tract diseases
title_fullStr The emerging role of the piRNA/PIWI complex in respiratory tract diseases
title_full_unstemmed The emerging role of the piRNA/PIWI complex in respiratory tract diseases
title_short The emerging role of the piRNA/PIWI complex in respiratory tract diseases
title_sort emerging role of the pirna/piwi complex in respiratory tract diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10010017/
https://www.ncbi.nlm.nih.gov/pubmed/36915129
http://dx.doi.org/10.1186/s12931-023-02367-9
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