Each side chain of cyclosporin A is not essential for high passive permeability across lipid bilayers

We compared the passive permeability of cyclosporin A (CsA) derivatives with side chain deletions across lipid bilayers. CsA maintained passive permeability after losing any one of the side chains, which suggests that the propensity of the backbone of CsA is an important component for high passive p...

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Detalles Bibliográficos
Autores principales: Ono, Takahiro, Tabata, Kazuhito V., Noji, Hiroyuki, Morimoto, Jumpei, Sando, Shinsuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10010161/
https://www.ncbi.nlm.nih.gov/pubmed/36922944
http://dx.doi.org/10.1039/d3ra01358h
Descripción
Sumario:We compared the passive permeability of cyclosporin A (CsA) derivatives with side chain deletions across lipid bilayers. CsA maintained passive permeability after losing any one of the side chains, which suggests that the propensity of the backbone of CsA is an important component for high passive permeability.

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