Each side chain of cyclosporin A is not essential for high passive permeability across lipid bilayers

We compared the passive permeability of cyclosporin A (CsA) derivatives with side chain deletions across lipid bilayers. CsA maintained passive permeability after losing any one of the side chains, which suggests that the propensity of the backbone of CsA is an important component for high passive p...

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Detalles Bibliográficos
Autores principales: Ono, Takahiro, Tabata, Kazuhito V., Noji, Hiroyuki, Morimoto, Jumpei, Sando, Shinsuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10010161/
https://www.ncbi.nlm.nih.gov/pubmed/36922944
http://dx.doi.org/10.1039/d3ra01358h
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author Ono, Takahiro
Tabata, Kazuhito V.
Noji, Hiroyuki
Morimoto, Jumpei
Sando, Shinsuke
author_facet Ono, Takahiro
Tabata, Kazuhito V.
Noji, Hiroyuki
Morimoto, Jumpei
Sando, Shinsuke
author_sort Ono, Takahiro
collection PubMed
description We compared the passive permeability of cyclosporin A (CsA) derivatives with side chain deletions across lipid bilayers. CsA maintained passive permeability after losing any one of the side chains, which suggests that the propensity of the backbone of CsA is an important component for high passive permeability.
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spelling pubmed-100101612023-03-14 Each side chain of cyclosporin A is not essential for high passive permeability across lipid bilayers Ono, Takahiro Tabata, Kazuhito V. Noji, Hiroyuki Morimoto, Jumpei Sando, Shinsuke RSC Adv Chemistry We compared the passive permeability of cyclosporin A (CsA) derivatives with side chain deletions across lipid bilayers. CsA maintained passive permeability after losing any one of the side chains, which suggests that the propensity of the backbone of CsA is an important component for high passive permeability. The Royal Society of Chemistry 2023-03-13 /pmc/articles/PMC10010161/ /pubmed/36922944 http://dx.doi.org/10.1039/d3ra01358h Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Ono, Takahiro
Tabata, Kazuhito V.
Noji, Hiroyuki
Morimoto, Jumpei
Sando, Shinsuke
Each side chain of cyclosporin A is not essential for high passive permeability across lipid bilayers
title Each side chain of cyclosporin A is not essential for high passive permeability across lipid bilayers
title_full Each side chain of cyclosporin A is not essential for high passive permeability across lipid bilayers
title_fullStr Each side chain of cyclosporin A is not essential for high passive permeability across lipid bilayers
title_full_unstemmed Each side chain of cyclosporin A is not essential for high passive permeability across lipid bilayers
title_short Each side chain of cyclosporin A is not essential for high passive permeability across lipid bilayers
title_sort each side chain of cyclosporin a is not essential for high passive permeability across lipid bilayers
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10010161/
https://www.ncbi.nlm.nih.gov/pubmed/36922944
http://dx.doi.org/10.1039/d3ra01358h
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