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Linking the relation between gut microbiota and glucocorticoid-induced osteoporosis
Osteoporosis (OP) is the most prevalent metabolic bone disease, characterized by the low bone mass and microarchitectural deterioration of bone tissue. Glucocorticoid (GC) clinically acts as one of the anti-inflammatory, immune-modulating, and therapeutic drugs, whereas the long-term use of GC may c...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Nature Singapore
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10010237/ https://www.ncbi.nlm.nih.gov/pubmed/36912997 http://dx.doi.org/10.1007/s00774-023-01415-0 |
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author | Zhou, Rui-Xin Zhang, Yuan-Wei Cao, Mu-Min Liu, Cun-Hao Rui, Yun-Feng Li, Ying-Juan |
author_facet | Zhou, Rui-Xin Zhang, Yuan-Wei Cao, Mu-Min Liu, Cun-Hao Rui, Yun-Feng Li, Ying-Juan |
author_sort | Zhou, Rui-Xin |
collection | PubMed |
description | Osteoporosis (OP) is the most prevalent metabolic bone disease, characterized by the low bone mass and microarchitectural deterioration of bone tissue. Glucocorticoid (GC) clinically acts as one of the anti-inflammatory, immune-modulating, and therapeutic drugs, whereas the long-term use of GC may cause rapid bone resorption, followed by prolonged and profound suppression of bone formation, resulting in the GC-induced OP (GIOP). GIOP ranks the first among secondary OP and is a pivotal risk for fracture, as well as high disability rate and mortality, at both societal and personal levels, vital costs. Gut microbiota (GM), known as the “second gene pool” of human body, is highly correlated with maintaining the bone mass and bone quality, and the relation between GM and bone metabolism has gradually become a research hotspot. Herein, combined with recent studies and based on the cross-linking relationship between GM and OP, this review is aimed to discuss the potential mechanisms of GM and its metabolites on the OP, as well as the moderating effects of GC on GM, thereby providing an emerging thought for prevention and treatment of GIOP. |
format | Online Article Text |
id | pubmed-10010237 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Springer Nature Singapore |
record_format | MEDLINE/PubMed |
spelling | pubmed-100102372023-03-14 Linking the relation between gut microbiota and glucocorticoid-induced osteoporosis Zhou, Rui-Xin Zhang, Yuan-Wei Cao, Mu-Min Liu, Cun-Hao Rui, Yun-Feng Li, Ying-Juan J Bone Miner Metab Review Article Osteoporosis (OP) is the most prevalent metabolic bone disease, characterized by the low bone mass and microarchitectural deterioration of bone tissue. Glucocorticoid (GC) clinically acts as one of the anti-inflammatory, immune-modulating, and therapeutic drugs, whereas the long-term use of GC may cause rapid bone resorption, followed by prolonged and profound suppression of bone formation, resulting in the GC-induced OP (GIOP). GIOP ranks the first among secondary OP and is a pivotal risk for fracture, as well as high disability rate and mortality, at both societal and personal levels, vital costs. Gut microbiota (GM), known as the “second gene pool” of human body, is highly correlated with maintaining the bone mass and bone quality, and the relation between GM and bone metabolism has gradually become a research hotspot. Herein, combined with recent studies and based on the cross-linking relationship between GM and OP, this review is aimed to discuss the potential mechanisms of GM and its metabolites on the OP, as well as the moderating effects of GC on GM, thereby providing an emerging thought for prevention and treatment of GIOP. Springer Nature Singapore 2023-03-13 2023 /pmc/articles/PMC10010237/ /pubmed/36912997 http://dx.doi.org/10.1007/s00774-023-01415-0 Text en © The Japanese Society Bone and Mineral Research 2023, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Review Article Zhou, Rui-Xin Zhang, Yuan-Wei Cao, Mu-Min Liu, Cun-Hao Rui, Yun-Feng Li, Ying-Juan Linking the relation between gut microbiota and glucocorticoid-induced osteoporosis |
title | Linking the relation between gut microbiota and glucocorticoid-induced osteoporosis |
title_full | Linking the relation between gut microbiota and glucocorticoid-induced osteoporosis |
title_fullStr | Linking the relation between gut microbiota and glucocorticoid-induced osteoporosis |
title_full_unstemmed | Linking the relation between gut microbiota and glucocorticoid-induced osteoporosis |
title_short | Linking the relation between gut microbiota and glucocorticoid-induced osteoporosis |
title_sort | linking the relation between gut microbiota and glucocorticoid-induced osteoporosis |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10010237/ https://www.ncbi.nlm.nih.gov/pubmed/36912997 http://dx.doi.org/10.1007/s00774-023-01415-0 |
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