An Informatics Bridge to Improve the Design and Efficiency of Phase I Clinical Trials for Anticancer Drug Combinations

In this study, we summarized critical databases of drug combination toxicity and pharmacokinetics. We further conducted a feasibility and utility study that demonstrates how different data sources can contribute to and assist phase I trial designs. Single-drug and drug combination toxicity and pharm...

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Detalles Bibliográficos
Autores principales: Wang, Lei, Wei, Lai, Zhang, Shijun, Cheng, Lijun, Shendre, Aditi, Carson, Williams, Chen, James L., Owen, Dwight, Gregory, Megan, Li, Lang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10010310/
https://www.ncbi.nlm.nih.gov/pubmed/36922938
http://dx.doi.org/10.1158/2767-9764.CRC-22-0160

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10010310/
https://www.ncbi.nlm.nih.gov/pubmed/36922938
http://dx.doi.org/10.1158/2767-9764.CRC-22-0160

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