A TCR-like CAR Promotes Sensitive Antigen Recognition and Controlled T-cell Expansion Upon mRNA Vaccination

Chimeric antigen receptor (CAR) T cells are efficacious in patients with B-cell malignancies, while their activity is limited in patients with solid tumors. We developed a novel heterodimeric TCR-like CAR (TCAR) designed to achieve optimal chain pairing and integration into the T-cell CD3 signaling...

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Detalles Bibliográficos
Autores principales: Birtel, Matthias, Voss, Ralf-Holger, Reinhard, Katharina, Rengstl, Benjamin, Ouchan, Yasmina, Michel, Kristina, Hayduk, Nina, Tillmann, Bodo, Becker, René, Suchan, Martin, Theobald, Matthias, Oehm, Petra, Türeci, Özlem, Sahin, Ugur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10010320/
https://www.ncbi.nlm.nih.gov/pubmed/36923303
http://dx.doi.org/10.1158/2767-9764.CRC-21-0154

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10010320/
https://www.ncbi.nlm.nih.gov/pubmed/36923303
http://dx.doi.org/10.1158/2767-9764.CRC-21-0154

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