Mixed Response to Cancer Immunotherapy is Driven by Intratumor Heterogeneity and Differential Interlesion Immune Infiltration

Some patients experience mixed response to immunotherapy, whose biological mechanisms and clinical impact have been obscure. We obtained two tumor samples from lymph node (LN) metastatic lesions in a same patient. Whole exome sequencing for the both tumors and single-cell sequencing for the both tum...

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Detalles Bibliográficos
Autores principales: Morinaga, Takao, Inozume, Takashi, Kawazu, Masahito, Ueda, Youki, Sax, Nicolas, Yamashita, Kazuo, Kawashima, Shusuke, Nagasaki, Joji, Ueno, Toshihide, Lin, Jason, Ohara, Yuuki, Kuwata, Takeshi, Yukami, Hiroki, Kawazoe, Akihito, Shitara, Kohei, Honobe-Tabuchi, Akiko, Ohnuma, Takehiro, Kawamura, Tatsuyoshi, Umeda, Yoshiyasu, Kawahara, Yu, Nakamura, Yasuhiro, Kiniwa, Yukiko, Morita, Ayako, Ichihara, Eiki, Kiura, Katsuyuki, Enokida, Tomohiro, Tahara, Makoto, Hasegawa, Yoshinori, Mano, Hiroyuki, Suzuki, Yutaka, Nishikawa, Hiroyoshi, Togashi, Yosuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10010332/
https://www.ncbi.nlm.nih.gov/pubmed/36923281
http://dx.doi.org/10.1158/2767-9764.CRC-22-0050

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