Depletion of Mannose Receptor–Positive Tumor-associated Macrophages via a Peptide-targeted Star-shaped Polyglutamate Inhibits Breast Cancer Progression in Mice

Although many studies have explored the depletion of tumor-associated macrophages (TAM) as a therapeutic strategy for solid tumors, currently available compounds suffer from poor efficacy and dose-limiting side effects. Here, we developed a novel TAM-depleting agent (“OximUNO”) that specifically tar...

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Detalles Bibliográficos
Autores principales: Lepland, Anni, Malfanti, Alessio, Haljasorg, Uku, Asciutto, Eliana K., Pickholz, Monica, Bringas, Mauro, Đorđević, Snežana, Salumäe, Liis, Peterson, Pärt, Teesalu, Tambet, Vicent, María J., Scodeller, Pablo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10010335/
https://www.ncbi.nlm.nih.gov/pubmed/36923553
http://dx.doi.org/10.1158/2767-9764.CRC-22-0043

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