The Wnt Pathway Inhibitor RXC004 Blocks Tumor Growth and Reverses Immune Evasion in Wnt Ligand–dependent Cancer Models

Wnt signaling is implicated in the etiology of gastrointestinal tract cancers. Targeting Wnt signaling is challenging due to on-target toxicity concerns and lack of druggable pathway components. We describe the discovery and characterization of RXC004, a potent and selective inhibitor of the membran...

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Detalles Bibliográficos
Autores principales: Phillips, Caroline, Bhamra, Inder, Eagle, Catherine, Flanagan, Eimear, Armer, Richard, Jones, Clifford D., Bingham, Matilda, Calcraft, Peter, Edmenson Cook, Alicia, Thompson, Ben, Woodcock, Simon A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10010340/
https://www.ncbi.nlm.nih.gov/pubmed/36922934
http://dx.doi.org/10.1158/2767-9764.CRC-21-0095

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