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Mavorixafor, an Orally Bioavailable CXCR4 Antagonist, Increases Immune Cell Infiltration and Inflammatory Status of Tumor Microenvironment in Patients with Melanoma

PURPOSE: Mavorixafor is an oral, selective inhibitor of the CXCR4 chemokine receptor that modulates immune cell trafficking. A biomarker-driven phase Ib study (NCT02823405) was conducted in 16 patients with melanoma to investigate the hypothesis that mavorixafor favorably modulates immune cell profi...

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Dettagli Bibliografici
Autori principali: Andtbacka, Robert H.I., Wang, Yan, Pierce, Robert H., Campbell, Jean S., Yushak, Melinda, Milhem, Mohammed, Ross, Merrick, Niland, Katie, Arbeit, Robert D., Parasuraman, Sudha, Bickley, Kris, Yeung, Cecilia CS, Aicher, Lauri D., Smythe, Kimberly S., Gan, Lu
Natura: Online Articolo testo
Lingua:English
Pubblicazione: American Association for Cancer Research 2022
Soggetti:
Accesso online:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10010370/
https://www.ncbi.nlm.nih.gov/pubmed/36923305
http://dx.doi.org/10.1158/2767-9764.CRC-22-0090