The MDM2 Inhibitor Navtemadlin Arrests Mouse Melanoma Growth In Vivo and Potentiates Radiotherapy

The tumor suppressor protein p53 is mutated in close to 50% of human tumors and is dysregulated in many others, for instance by silencing or loss of p14(ARF). Under steady-state conditions, the two E3 ligases MDM2/MDM4 interact with and inhibit the transcriptional activity of p53. Inhibition of p53–...

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Detalles Bibliográficos
Autores principales: Ingelshed, Katrine, Spiegelberg, Diana, Kannan, Pavitra, Påvénius, Linnéa, Hacheney, Jessica, Jiang, Long, Eisinger, Silke, Lianoudaki, Danai, Lama, Dilraj, Castillo, Francisca, Bosdotter, Cecilia, Kretzschmar, Warren W., Al-Radi, Omayma, Fritz, Nicolas, Villablanca, Eduardo J., Karlsson, Mikael C. I., Wermeling, Fredrik, Nestor, Marika, Lane, David P., Sedimbi, Saikiran K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10010373/
https://www.ncbi.nlm.nih.gov/pubmed/36922937
http://dx.doi.org/10.1158/2767-9764.CRC-22-0053

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