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Presentation and Management of Orbito-Ocular Malignancies in a Tertiary Institution in Southwest Nigeria

PURPOSE: The aim of this study was to review the management of orbito-ocular malignancies in the Departments of Radiotherapy and Ophthalmology, Lagos University Teaching Hospital, between January 1997 and December 2011 in comparison to previous and recent studies globally. MATERIALS AND METHODS: Thi...

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Autores principales: Alabi, Adewumi Olabimpe, Alabi, Adegboyega Sunday, Sowunmi, Anthonia Chima, Ololade, Kehinde O., Adegboyega, Bolanle Comfort, Habeebu, Muhammad Yaqub M., Fatiregun, Omolara Amina, Akinsola, Folasade Bolanle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10010579/
https://www.ncbi.nlm.nih.gov/pubmed/36923813
http://dx.doi.org/10.4103/jwas.jwas_37_21
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author Alabi, Adewumi Olabimpe
Alabi, Adegboyega Sunday
Sowunmi, Anthonia Chima
Ololade, Kehinde O.
Adegboyega, Bolanle Comfort
Habeebu, Muhammad Yaqub M.
Fatiregun, Omolara Amina
Akinsola, Folasade Bolanle
author_facet Alabi, Adewumi Olabimpe
Alabi, Adegboyega Sunday
Sowunmi, Anthonia Chima
Ololade, Kehinde O.
Adegboyega, Bolanle Comfort
Habeebu, Muhammad Yaqub M.
Fatiregun, Omolara Amina
Akinsola, Folasade Bolanle
author_sort Alabi, Adewumi Olabimpe
collection PubMed
description PURPOSE: The aim of this study was to review the management of orbito-ocular malignancies in the Departments of Radiotherapy and Ophthalmology, Lagos University Teaching Hospital, between January 1997 and December 2011 in comparison to previous and recent studies globally. MATERIALS AND METHODS: This was a retrospective study of orbito-ocular malignancies seen at the Departments of Radiotherapy and Ophthalmology, Lagos University Teaching Hospital from 1997 to 2011. Case files and treatment cards were retrieved through the Medical Records department and the information required was extracted with the aid of a data extraction form. RESULTS: A total of 98 cases with histologically confirmed orbito-ocular malignancies seen during the 15-year study period were analysed. Retinoblastoma (51 [52.0%]) was the most common orbito-ocular malignancies seen in children, whereas squamous cell carcinoma of the conjunctiva (25 [25.5%]) was the most common in adults. Seventeen (17%) patients had a combination of radiotherapy, surgery, and chemotherapy. Thirty (33%) had enucleation, whereas 33 (36%) had exenteration. Thirty-six patients had chemotherapy, whereas 44 patients benefited from radiotherapy, and radical treatment was offered to 24 patients. Total radical treatment dose was 35–65 Gy in 20–35 fractions over 4–7 weeks. Most of the patients (84 [85.7%]) were lost to follow up. Five (5.1%) died from disease progression and four (4.1%) are still alive and on regular follow-up. CONCLUSION: This study showed that the use of multimodality treatment was implemented but did not improve survival because the majority of patients presented late. The need for a collaborative effort in early detection and prompt referral for treatment of cancer cases cannot be overemphasised.
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spelling pubmed-100105792023-03-14 Presentation and Management of Orbito-Ocular Malignancies in a Tertiary Institution in Southwest Nigeria Alabi, Adewumi Olabimpe Alabi, Adegboyega Sunday Sowunmi, Anthonia Chima Ololade, Kehinde O. Adegboyega, Bolanle Comfort Habeebu, Muhammad Yaqub M. Fatiregun, Omolara Amina Akinsola, Folasade Bolanle J West Afr Coll Surg Original Article PURPOSE: The aim of this study was to review the management of orbito-ocular malignancies in the Departments of Radiotherapy and Ophthalmology, Lagos University Teaching Hospital, between January 1997 and December 2011 in comparison to previous and recent studies globally. MATERIALS AND METHODS: This was a retrospective study of orbito-ocular malignancies seen at the Departments of Radiotherapy and Ophthalmology, Lagos University Teaching Hospital from 1997 to 2011. Case files and treatment cards were retrieved through the Medical Records department and the information required was extracted with the aid of a data extraction form. RESULTS: A total of 98 cases with histologically confirmed orbito-ocular malignancies seen during the 15-year study period were analysed. Retinoblastoma (51 [52.0%]) was the most common orbito-ocular malignancies seen in children, whereas squamous cell carcinoma of the conjunctiva (25 [25.5%]) was the most common in adults. Seventeen (17%) patients had a combination of radiotherapy, surgery, and chemotherapy. Thirty (33%) had enucleation, whereas 33 (36%) had exenteration. Thirty-six patients had chemotherapy, whereas 44 patients benefited from radiotherapy, and radical treatment was offered to 24 patients. Total radical treatment dose was 35–65 Gy in 20–35 fractions over 4–7 weeks. Most of the patients (84 [85.7%]) were lost to follow up. Five (5.1%) died from disease progression and four (4.1%) are still alive and on regular follow-up. CONCLUSION: This study showed that the use of multimodality treatment was implemented but did not improve survival because the majority of patients presented late. The need for a collaborative effort in early detection and prompt referral for treatment of cancer cases cannot be overemphasised. Wolters Kluwer - Medknow 2023 2023-01-18 /pmc/articles/PMC10010579/ /pubmed/36923813 http://dx.doi.org/10.4103/jwas.jwas_37_21 Text en Copyright: © 2023 Journal of West African College of Surgeons https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Alabi, Adewumi Olabimpe
Alabi, Adegboyega Sunday
Sowunmi, Anthonia Chima
Ololade, Kehinde O.
Adegboyega, Bolanle Comfort
Habeebu, Muhammad Yaqub M.
Fatiregun, Omolara Amina
Akinsola, Folasade Bolanle
Presentation and Management of Orbito-Ocular Malignancies in a Tertiary Institution in Southwest Nigeria
title Presentation and Management of Orbito-Ocular Malignancies in a Tertiary Institution in Southwest Nigeria
title_full Presentation and Management of Orbito-Ocular Malignancies in a Tertiary Institution in Southwest Nigeria
title_fullStr Presentation and Management of Orbito-Ocular Malignancies in a Tertiary Institution in Southwest Nigeria
title_full_unstemmed Presentation and Management of Orbito-Ocular Malignancies in a Tertiary Institution in Southwest Nigeria
title_short Presentation and Management of Orbito-Ocular Malignancies in a Tertiary Institution in Southwest Nigeria
title_sort presentation and management of orbito-ocular malignancies in a tertiary institution in southwest nigeria
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10010579/
https://www.ncbi.nlm.nih.gov/pubmed/36923813
http://dx.doi.org/10.4103/jwas.jwas_37_21
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