SMITH: spatially constrained stochastic model for simulation of intra-tumour heterogeneity

MOTIVATION: Simulations of cancer evolution are highly useful to study the effects of selection and mutation rates on cellular fitness. However, most methods are either lattice-based and cannot simulate realistically sized tumours, or they omit spatial constraints and lack the clonal dynamics of rea...

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Detalles Bibliográficos
Autores principales: Streck, Adam, Kaufmann, Tom L, Schwarz, Roland F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10010604/
https://www.ncbi.nlm.nih.gov/pubmed/36825830
http://dx.doi.org/10.1093/bioinformatics/btad102

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10010604/
https://www.ncbi.nlm.nih.gov/pubmed/36825830
http://dx.doi.org/10.1093/bioinformatics/btad102

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