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SMITH: spatially constrained stochastic model for simulation of intra-tumour heterogeneity
MOTIVATION: Simulations of cancer evolution are highly useful to study the effects of selection and mutation rates on cellular fitness. However, most methods are either lattice-based and cannot simulate realistically sized tumours, or they omit spatial constraints and lack the clonal dynamics of rea...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10010604/ https://www.ncbi.nlm.nih.gov/pubmed/36825830 http://dx.doi.org/10.1093/bioinformatics/btad102 |