C/EBPβ cooperates with MYB to maintain the oncogenic program of AML cells

Studies on the role of transcription factor MYB in acute myeloid leukemia (AML) have identified MYB as a key regulator of a transcriptional program for self-renewal of AML cells. Recent work summarized here has now highlighted the CCAAT-box/enhancer binding protein beta (C/EBPβ) as an essential fact...

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Detalles Bibliográficos
Autor principal: Klempnauer, Karl-Heinz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2023
Materias:
Editorial Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10010626/
https://www.ncbi.nlm.nih.gov/pubmed/36913305
http://dx.doi.org/10.18632/oncotarget.28377
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author Klempnauer, Karl-Heinz
author_facet Klempnauer, Karl-Heinz
author_sort Klempnauer, Karl-Heinz
collection PubMed
description Studies on the role of transcription factor MYB in acute myeloid leukemia (AML) have identified MYB as a key regulator of a transcriptional program for self-renewal of AML cells. Recent work summarized here has now highlighted the CCAAT-box/enhancer binding protein beta (C/EBPβ) as an essential factor and potential therapeutic target that cooperates with MYB and coactivator p300 in the maintenance of the leukemic cells.
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spelling pubmed-100106262023-03-14 C/EBPβ cooperates with MYB to maintain the oncogenic program of AML cells Klempnauer, Karl-Heinz Oncotarget Editorial Perspective Studies on the role of transcription factor MYB in acute myeloid leukemia (AML) have identified MYB as a key regulator of a transcriptional program for self-renewal of AML cells. Recent work summarized here has now highlighted the CCAAT-box/enhancer binding protein beta (C/EBPβ) as an essential factor and potential therapeutic target that cooperates with MYB and coactivator p300 in the maintenance of the leukemic cells. Impact Journals LLC 2023-03-11 /pmc/articles/PMC10010626/ /pubmed/36913305 http://dx.doi.org/10.18632/oncotarget.28377 Text en Copyright: © 2023 Klempnauer. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Editorial Perspective
Klempnauer, Karl-Heinz
C/EBPβ cooperates with MYB to maintain the oncogenic program of AML cells
title C/EBPβ cooperates with MYB to maintain the oncogenic program of AML cells
title_full C/EBPβ cooperates with MYB to maintain the oncogenic program of AML cells
title_fullStr C/EBPβ cooperates with MYB to maintain the oncogenic program of AML cells
title_full_unstemmed C/EBPβ cooperates with MYB to maintain the oncogenic program of AML cells
title_short C/EBPβ cooperates with MYB to maintain the oncogenic program of AML cells
title_sort c/ebpβ cooperates with myb to maintain the oncogenic program of aml cells
topic Editorial Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10010626/
https://www.ncbi.nlm.nih.gov/pubmed/36913305
http://dx.doi.org/10.18632/oncotarget.28377
work_keys_str_mv AT klempnauerkarlheinz cebpbcooperateswithmybtomaintaintheoncogenicprogramofamlcells

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