A transcriptional constraint mechanism limits the homeostatic response to activity deprivation in mammalian neocortex

Healthy neuronal networks rely on homeostatic plasticity to maintain stable firing rates despite changing synaptic drive. These mechanisms, however, can themselves be destabilizing if activated inappropriately or excessively. For example, prolonged activity deprivation can lead to rebound hyperactiv...

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Detalles Bibliográficos
Autores principales: Valakh, Vera, Wise, Derek, Zhu, Xiaoyue Aelita, Sha, Mingqi, Fok, Jaidyn, Van Hooser, Stephen D, Schectman, Robin, Cepeda, Isabel, Kirk, Ryan, O'Toole, Sean M, Nelson, Sacha B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10010687/
https://www.ncbi.nlm.nih.gov/pubmed/36749029
http://dx.doi.org/10.7554/eLife.74899

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