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Renal denervation in the antihypertensive arsenal – knowns and known unknowns
Even though it has been more than a decade since renal denervation (RDN) was first used to treat hypertension and an intense effort on researching this therapy has been made, it is still not clear how RDN fits into the antihypertensive arsenal. There is no question that RDN lowers blood pressure (BP...
Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10010701/ https://www.ncbi.nlm.nih.gov/pubmed/36052518 http://dx.doi.org/10.1097/HJH.0000000000003171 |
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author | Messerli, Franz H. Bavishi, Chirag Brguljan, Jana Burnier, Michel Dobner, Stephan Elijovich, Fernando Ferdinand, Keith C. Kjeldsen, Sverre Laffer, Cheryl L. S Ram, C. Venkata Rexhaj, Emrush Ruilope, Luis M. Shalaeva, Evgeniya V. Siontis, George C.M. Staessen, Jan A. Textor, Stephen C. Vongpatanasin, Wanpen Vogt, Liffert Volpe, Massimo Wang, Jiguang Williams, Bryan |
author_facet | Messerli, Franz H. Bavishi, Chirag Brguljan, Jana Burnier, Michel Dobner, Stephan Elijovich, Fernando Ferdinand, Keith C. Kjeldsen, Sverre Laffer, Cheryl L. S Ram, C. Venkata Rexhaj, Emrush Ruilope, Luis M. Shalaeva, Evgeniya V. Siontis, George C.M. Staessen, Jan A. Textor, Stephen C. Vongpatanasin, Wanpen Vogt, Liffert Volpe, Massimo Wang, Jiguang Williams, Bryan |
author_sort | Messerli, Franz H. |
collection | PubMed |
description | Even though it has been more than a decade since renal denervation (RDN) was first used to treat hypertension and an intense effort on researching this therapy has been made, it is still not clear how RDN fits into the antihypertensive arsenal. There is no question that RDN lowers blood pressure (BP), it does so to an extent at best corresponding to one antihypertensive drug. The procedure has an excellent safety record. However, it remains clinically impossible to predict whose BP responds to RDN and whose does not. Long-term efficacy data on BP reduction are still unconvincing despite the recent results in the SPYRAL HTN-ON MED trial; experimental studies indicate that reinnervation is occurring after RDN. Although BP is an acceptable surrogate endpoint, there is complete lack of outcome data with RDN. Clear indications for RDN are lacking although patients with resistant hypertension, those with documented increase in activity of the sympathetic system and perhaps those who desire to take fewest medication may be considered. |
format | Online Article Text |
id | pubmed-10010701 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-100107012023-03-14 Renal denervation in the antihypertensive arsenal – knowns and known unknowns Messerli, Franz H. Bavishi, Chirag Brguljan, Jana Burnier, Michel Dobner, Stephan Elijovich, Fernando Ferdinand, Keith C. Kjeldsen, Sverre Laffer, Cheryl L. S Ram, C. Venkata Rexhaj, Emrush Ruilope, Luis M. Shalaeva, Evgeniya V. Siontis, George C.M. Staessen, Jan A. Textor, Stephen C. Vongpatanasin, Wanpen Vogt, Liffert Volpe, Massimo Wang, Jiguang Williams, Bryan J Hypertens Reviews Even though it has been more than a decade since renal denervation (RDN) was first used to treat hypertension and an intense effort on researching this therapy has been made, it is still not clear how RDN fits into the antihypertensive arsenal. There is no question that RDN lowers blood pressure (BP), it does so to an extent at best corresponding to one antihypertensive drug. The procedure has an excellent safety record. However, it remains clinically impossible to predict whose BP responds to RDN and whose does not. Long-term efficacy data on BP reduction are still unconvincing despite the recent results in the SPYRAL HTN-ON MED trial; experimental studies indicate that reinnervation is occurring after RDN. Although BP is an acceptable surrogate endpoint, there is complete lack of outcome data with RDN. Clear indications for RDN are lacking although patients with resistant hypertension, those with documented increase in activity of the sympathetic system and perhaps those who desire to take fewest medication may be considered. Lippincott Williams & Wilkins 2023-03-07 2022-10 /pmc/articles/PMC10010701/ /pubmed/36052518 http://dx.doi.org/10.1097/HJH.0000000000003171 Text en Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) |
spellingShingle | Reviews Messerli, Franz H. Bavishi, Chirag Brguljan, Jana Burnier, Michel Dobner, Stephan Elijovich, Fernando Ferdinand, Keith C. Kjeldsen, Sverre Laffer, Cheryl L. S Ram, C. Venkata Rexhaj, Emrush Ruilope, Luis M. Shalaeva, Evgeniya V. Siontis, George C.M. Staessen, Jan A. Textor, Stephen C. Vongpatanasin, Wanpen Vogt, Liffert Volpe, Massimo Wang, Jiguang Williams, Bryan Renal denervation in the antihypertensive arsenal – knowns and known unknowns |
title | Renal denervation in the antihypertensive arsenal – knowns and known unknowns |
title_full | Renal denervation in the antihypertensive arsenal – knowns and known unknowns |
title_fullStr | Renal denervation in the antihypertensive arsenal – knowns and known unknowns |
title_full_unstemmed | Renal denervation in the antihypertensive arsenal – knowns and known unknowns |
title_short | Renal denervation in the antihypertensive arsenal – knowns and known unknowns |
title_sort | renal denervation in the antihypertensive arsenal – knowns and known unknowns |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10010701/ https://www.ncbi.nlm.nih.gov/pubmed/36052518 http://dx.doi.org/10.1097/HJH.0000000000003171 |
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