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Clinicodemographic profile of chronic liver disease patients at a tertiary care hospital: a retrospective analysis

With the global burden of chronic liver disease (CLD) on the rise, especially due to the rise in obesity and metabolic syndrome, a third-world country like Nepal faces a different problem. With alcohol intake being rooted in Nepalese culture, alcoholic liver disease (ALD) is the most common cause of...

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Autores principales: Shrestha, Anish K., Shrestha, Anisha, Shah, Sangam, Bhandari, Aashna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10010787/
https://www.ncbi.nlm.nih.gov/pubmed/36923767
http://dx.doi.org/10.1097/MS9.0000000000000248
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author Shrestha, Anish K.
Shrestha, Anisha
Shah, Sangam
Bhandari, Aashna
author_facet Shrestha, Anish K.
Shrestha, Anisha
Shah, Sangam
Bhandari, Aashna
author_sort Shrestha, Anish K.
collection PubMed
description With the global burden of chronic liver disease (CLD) on the rise, especially due to the rise in obesity and metabolic syndrome, a third-world country like Nepal faces a different problem. With alcohol intake being rooted in Nepalese culture, alcoholic liver disease (ALD) is the most common cause of CLD in our society. METHODS: This is a retrospective observational study conducted in the inpatient ward of the Department of Gastroenterology at the University in Nepal. Ethical approval was taken from the Institutional Review Committee, and a structured questionnaire format was used to record the data retrospectively using admission log books and admission sheets. Demographic data regarding age, sex, and address were collected, while the form of decompensation during presentation was used as a source of clinical data. For statistical analysis, see SPSS 21 (IBM Corp., Released 2012. IBM SPSS Statistics for Windows, Version 21.0; IBM Corp.) was used. RESULTS: A male-to-female ratio of 2:1 was found, with ALD the most common cause of CLD in admitted patients. Similarly, the majority of patients were admitted due to ascites, which was compounded by spontaneous bacterial peritonitis. 93.60% of patients admitted with CLD had a deranged prothrombin time, while only about a third of patients had elevated aspartate aminotransferase and/or alanine aminotransferase. CONCLUSION: The large burden of ALD highlights the importance of awareness programs at the community level, which have been neglected till date.
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spelling pubmed-100107872023-03-14 Clinicodemographic profile of chronic liver disease patients at a tertiary care hospital: a retrospective analysis Shrestha, Anish K. Shrestha, Anisha Shah, Sangam Bhandari, Aashna Ann Med Surg (Lond) Original Research With the global burden of chronic liver disease (CLD) on the rise, especially due to the rise in obesity and metabolic syndrome, a third-world country like Nepal faces a different problem. With alcohol intake being rooted in Nepalese culture, alcoholic liver disease (ALD) is the most common cause of CLD in our society. METHODS: This is a retrospective observational study conducted in the inpatient ward of the Department of Gastroenterology at the University in Nepal. Ethical approval was taken from the Institutional Review Committee, and a structured questionnaire format was used to record the data retrospectively using admission log books and admission sheets. Demographic data regarding age, sex, and address were collected, while the form of decompensation during presentation was used as a source of clinical data. For statistical analysis, see SPSS 21 (IBM Corp., Released 2012. IBM SPSS Statistics for Windows, Version 21.0; IBM Corp.) was used. RESULTS: A male-to-female ratio of 2:1 was found, with ALD the most common cause of CLD in admitted patients. Similarly, the majority of patients were admitted due to ascites, which was compounded by spontaneous bacterial peritonitis. 93.60% of patients admitted with CLD had a deranged prothrombin time, while only about a third of patients had elevated aspartate aminotransferase and/or alanine aminotransferase. CONCLUSION: The large burden of ALD highlights the importance of awareness programs at the community level, which have been neglected till date. Lippincott Williams & Wilkins 2023-02-17 /pmc/articles/PMC10010787/ /pubmed/36923767 http://dx.doi.org/10.1097/MS9.0000000000000248 Text en Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (https://creativecommons.org/licenses/by/4.0/) (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/)
spellingShingle Original Research
Shrestha, Anish K.
Shrestha, Anisha
Shah, Sangam
Bhandari, Aashna
Clinicodemographic profile of chronic liver disease patients at a tertiary care hospital: a retrospective analysis
title Clinicodemographic profile of chronic liver disease patients at a tertiary care hospital: a retrospective analysis
title_full Clinicodemographic profile of chronic liver disease patients at a tertiary care hospital: a retrospective analysis
title_fullStr Clinicodemographic profile of chronic liver disease patients at a tertiary care hospital: a retrospective analysis
title_full_unstemmed Clinicodemographic profile of chronic liver disease patients at a tertiary care hospital: a retrospective analysis
title_short Clinicodemographic profile of chronic liver disease patients at a tertiary care hospital: a retrospective analysis
title_sort clinicodemographic profile of chronic liver disease patients at a tertiary care hospital: a retrospective analysis
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10010787/
https://www.ncbi.nlm.nih.gov/pubmed/36923767
http://dx.doi.org/10.1097/MS9.0000000000000248
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