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Effect of the olive leaf extract in chronic spinal cord injury model: an experimental research
Posttraumatic myelopathy is defined as a spinal cord injury (SCI) that results in varying degrees of motor and sensory deficits. The degree of ‘secondary damage,’ which is caused by a variety of cellular, molecular, and biochemical cascades is linked to the outcome of SCI. According to research, the...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10010806/ https://www.ncbi.nlm.nih.gov/pubmed/36923747 http://dx.doi.org/10.1097/MS9.0000000000000085 |
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author | Nasution, Iqbal P.A. Ibrahim, Sabri Riawan, Wibi |
author_facet | Nasution, Iqbal P.A. Ibrahim, Sabri Riawan, Wibi |
author_sort | Nasution, Iqbal P.A. |
collection | PubMed |
description | Posttraumatic myelopathy is defined as a spinal cord injury (SCI) that results in varying degrees of motor and sensory deficits. The degree of ‘secondary damage,’ which is caused by a variety of cellular, molecular, and biochemical cascades is linked to the outcome of SCI. According to research, the beneficial effects of oleuropein and its derivatives have been linked to radical scavenging/antioxidant actions and anti-inflammatory effects. MATERIALS AND METHODS: This study was divided into six groups: control negative (sham-operated) group, control positive 1 and 2 (early chronic and chronic), treatment groups 1, 2, and 3 (prophylactic, concomitant, and late). Olive leaf extract (OLE) given dose was 350 mg/kg body weight. Blood was taken from the left corotic artery before the animals were terminated, seromarker assessment, enzyme-linked immunosorbent assay of IL-6, TNF-α, brain-derived neurotrophic factor (BDNF), and assessment of functional motoric outcome before the animal was terminated. RESULTS: Chronic spinal cord compression increased serum levels of IL-6, TNF-α, and decreased serum level of BDNF. OLE 350 mg/kg body weight decreased serum levels of IL-6, TNF-α and increased functional motoric outcome, especially in prophylactic and concomitant therapy. DISCUSSION: These findings indicate that OLE may be effective in protecting chronic SCI model. CONCLUSION: Oleuropein has a potential effect to reduce the IL-6 and TNF-α in rabbit model of SCI, and the BDNF value risen after the administration of Oleuropein. |
format | Online Article Text |
id | pubmed-10010806 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-100108062023-03-14 Effect of the olive leaf extract in chronic spinal cord injury model: an experimental research Nasution, Iqbal P.A. Ibrahim, Sabri Riawan, Wibi Ann Med Surg (Lond) Original Research Posttraumatic myelopathy is defined as a spinal cord injury (SCI) that results in varying degrees of motor and sensory deficits. The degree of ‘secondary damage,’ which is caused by a variety of cellular, molecular, and biochemical cascades is linked to the outcome of SCI. According to research, the beneficial effects of oleuropein and its derivatives have been linked to radical scavenging/antioxidant actions and anti-inflammatory effects. MATERIALS AND METHODS: This study was divided into six groups: control negative (sham-operated) group, control positive 1 and 2 (early chronic and chronic), treatment groups 1, 2, and 3 (prophylactic, concomitant, and late). Olive leaf extract (OLE) given dose was 350 mg/kg body weight. Blood was taken from the left corotic artery before the animals were terminated, seromarker assessment, enzyme-linked immunosorbent assay of IL-6, TNF-α, brain-derived neurotrophic factor (BDNF), and assessment of functional motoric outcome before the animal was terminated. RESULTS: Chronic spinal cord compression increased serum levels of IL-6, TNF-α, and decreased serum level of BDNF. OLE 350 mg/kg body weight decreased serum levels of IL-6, TNF-α and increased functional motoric outcome, especially in prophylactic and concomitant therapy. DISCUSSION: These findings indicate that OLE may be effective in protecting chronic SCI model. CONCLUSION: Oleuropein has a potential effect to reduce the IL-6 and TNF-α in rabbit model of SCI, and the BDNF value risen after the administration of Oleuropein. Lippincott Williams & Wilkins 2023-03-09 /pmc/articles/PMC10010806/ /pubmed/36923747 http://dx.doi.org/10.1097/MS9.0000000000000085 Text en Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) |
spellingShingle | Original Research Nasution, Iqbal P.A. Ibrahim, Sabri Riawan, Wibi Effect of the olive leaf extract in chronic spinal cord injury model: an experimental research |
title | Effect of the olive leaf extract in chronic spinal cord injury model: an experimental research |
title_full | Effect of the olive leaf extract in chronic spinal cord injury model: an experimental research |
title_fullStr | Effect of the olive leaf extract in chronic spinal cord injury model: an experimental research |
title_full_unstemmed | Effect of the olive leaf extract in chronic spinal cord injury model: an experimental research |
title_short | Effect of the olive leaf extract in chronic spinal cord injury model: an experimental research |
title_sort | effect of the olive leaf extract in chronic spinal cord injury model: an experimental research |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10010806/ https://www.ncbi.nlm.nih.gov/pubmed/36923747 http://dx.doi.org/10.1097/MS9.0000000000000085 |
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