Not All Glittering Bone Lesions Are Gold: A Case of Sclerotic Bone Lesions with Elevated (68) Ga PSMA and (99m) Tc HDP Uptake with No Signs of Malignancy

Gallium-68 prostate-specific membrane antigen positron emission tomography/computed tomography ( (68) Ga PSMA PET/CT) outperforms CT and bone scintigraphy in terms of diagnostic accuracy for the primary staging of prostate cancer and has become widely used. However, (68) Ga PSMA uptake is also encou...

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Autores principales: Bentestuen, Morten, Elkjær, Maria Carlsen, Zacho, Helle D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Thieme Medical and Scientific Publishers Pvt. Ltd. 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10010856/
https://www.ncbi.nlm.nih.gov/pubmed/36923978
http://dx.doi.org/10.1055/s-0042-1758805
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author Bentestuen, Morten
Elkjær, Maria Carlsen
Zacho, Helle D.
author_facet Bentestuen, Morten
Elkjær, Maria Carlsen
Zacho, Helle D.
author_sort Bentestuen, Morten
collection PubMed
description Gallium-68 prostate-specific membrane antigen positron emission tomography/computed tomography ( (68) Ga PSMA PET/CT) outperforms CT and bone scintigraphy in terms of diagnostic accuracy for the primary staging of prostate cancer and has become widely used. However, (68) Ga PSMA uptake is also encountered in nonprostatic tissue. We present a 63-year-old male with newly diagnosed high-risk prostate cancer who underwent bone scintigraphy with single-photon emission computed tomography/computed tomography (SPECT/CT), which showed inhomogeneous elevated uptake in sclerotic bone lesions in the pelvis. Likewise, (68) Ga PSMA PET/CT revealed inhomogeneous uptake in the same areas. Subsequent biopsy revealed hyperplastic bone marrow without signs of malignancy. The patient underwent radical prostatectomy, and the prostate-specific antigen level dropped to less than 0.1 ng/mL.
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spelling pubmed-100108562023-03-14 Not All Glittering Bone Lesions Are Gold: A Case of Sclerotic Bone Lesions with Elevated (68) Ga PSMA and (99m) Tc HDP Uptake with No Signs of Malignancy Bentestuen, Morten Elkjær, Maria Carlsen Zacho, Helle D. World J Nucl Med Gallium-68 prostate-specific membrane antigen positron emission tomography/computed tomography ( (68) Ga PSMA PET/CT) outperforms CT and bone scintigraphy in terms of diagnostic accuracy for the primary staging of prostate cancer and has become widely used. However, (68) Ga PSMA uptake is also encountered in nonprostatic tissue. We present a 63-year-old male with newly diagnosed high-risk prostate cancer who underwent bone scintigraphy with single-photon emission computed tomography/computed tomography (SPECT/CT), which showed inhomogeneous elevated uptake in sclerotic bone lesions in the pelvis. Likewise, (68) Ga PSMA PET/CT revealed inhomogeneous uptake in the same areas. Subsequent biopsy revealed hyperplastic bone marrow without signs of malignancy. The patient underwent radical prostatectomy, and the prostate-specific antigen level dropped to less than 0.1 ng/mL. Thieme Medical and Scientific Publishers Pvt. Ltd. 2022-12-20 /pmc/articles/PMC10010856/ /pubmed/36923978 http://dx.doi.org/10.1055/s-0042-1758805 Text en The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. ( https://creativecommons.org/licenses/by/4.0/ ) https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Bentestuen, Morten
Elkjær, Maria Carlsen
Zacho, Helle D.
Not All Glittering Bone Lesions Are Gold: A Case of Sclerotic Bone Lesions with Elevated (68) Ga PSMA and (99m) Tc HDP Uptake with No Signs of Malignancy
title Not All Glittering Bone Lesions Are Gold: A Case of Sclerotic Bone Lesions with Elevated (68) Ga PSMA and (99m) Tc HDP Uptake with No Signs of Malignancy
title_full Not All Glittering Bone Lesions Are Gold: A Case of Sclerotic Bone Lesions with Elevated (68) Ga PSMA and (99m) Tc HDP Uptake with No Signs of Malignancy
title_fullStr Not All Glittering Bone Lesions Are Gold: A Case of Sclerotic Bone Lesions with Elevated (68) Ga PSMA and (99m) Tc HDP Uptake with No Signs of Malignancy
title_full_unstemmed Not All Glittering Bone Lesions Are Gold: A Case of Sclerotic Bone Lesions with Elevated (68) Ga PSMA and (99m) Tc HDP Uptake with No Signs of Malignancy
title_short Not All Glittering Bone Lesions Are Gold: A Case of Sclerotic Bone Lesions with Elevated (68) Ga PSMA and (99m) Tc HDP Uptake with No Signs of Malignancy
title_sort not all glittering bone lesions are gold: a case of sclerotic bone lesions with elevated (68) ga psma and (99m) tc hdp uptake with no signs of malignancy
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10010856/
https://www.ncbi.nlm.nih.gov/pubmed/36923978
http://dx.doi.org/10.1055/s-0042-1758805
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