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A systemic review on medicinal plants and their bioactive constituents against avian influenza and further confirmation through in-silico analysis
BACKGROUND: Avian influenza or more commonly known as bird flu is a widespread infectious disease in poultry. This review aims to accumulate information of different natural plant sources that can aid in combating this disease. Influenza virus (IV) is known for its ability to mutate and infect diffe...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10011005/ https://www.ncbi.nlm.nih.gov/pubmed/36925514 http://dx.doi.org/10.1016/j.heliyon.2023.e14386 |
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author | Dutta, Ashit Kumar Gazi, Md Shamim Uddin, Shaikh Jamal |
author_facet | Dutta, Ashit Kumar Gazi, Md Shamim Uddin, Shaikh Jamal |
author_sort | Dutta, Ashit Kumar |
collection | PubMed |
description | BACKGROUND: Avian influenza or more commonly known as bird flu is a widespread infectious disease in poultry. This review aims to accumulate information of different natural plant sources that can aid in combating this disease. Influenza virus (IV) is known for its ability to mutate and infect different species (including humans) and cause fatal consequences. METHODS: Total 33 plants and 4 natural compounds were identified and documented. Molecular docking was performed against the target viral protein neuraminidase (NA), with some plant based natural compounds and compared their results with standard drugs Oseltamivir and Zanamivir to obtain novel drug targets for influenza in chickens. RESULTS: It was seen that most extracts exhibit their action by interacting with viral hemagglutinin or neuraminidase and inhibit viral entry or release from the host cell. Some plants also interacted with the viral RNA replication or by reducing proinflammatory cytokines. Ethanol was mostly used for extraction. Among all the plants Theobroma cacao, Capparis Sinaica Veil, Androgarphis paniculate, Thallasodendron cillatum, Sinularia candidula, Larcifomes officinalis, Lenzites betulina, Datronia molis, Trametes gibbose exhibited their activity with least concentration (below 10 μg/ml). The dockings results showed that some natural compounds (5,7- dimethoxyflavone, Aloe emodin, Anthocyanins, Quercetin, Hemanthamine, Lyocrine, Terpenoid EA showed satisfactory binding affinity and binding specificity with viral neuraminidase compared to the synthetic drugs. CONCLUSION: This review clusters up to date information of effective herbal plants to bolster future influenza treatment research in chickens. The in-silico analysis also suggests some potential targets for future drug development but these require more clinical analysis. |
format | Online Article Text |
id | pubmed-10011005 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-100110052023-03-15 A systemic review on medicinal plants and their bioactive constituents against avian influenza and further confirmation through in-silico analysis Dutta, Ashit Kumar Gazi, Md Shamim Uddin, Shaikh Jamal Heliyon Review Article BACKGROUND: Avian influenza or more commonly known as bird flu is a widespread infectious disease in poultry. This review aims to accumulate information of different natural plant sources that can aid in combating this disease. Influenza virus (IV) is known for its ability to mutate and infect different species (including humans) and cause fatal consequences. METHODS: Total 33 plants and 4 natural compounds were identified and documented. Molecular docking was performed against the target viral protein neuraminidase (NA), with some plant based natural compounds and compared their results with standard drugs Oseltamivir and Zanamivir to obtain novel drug targets for influenza in chickens. RESULTS: It was seen that most extracts exhibit their action by interacting with viral hemagglutinin or neuraminidase and inhibit viral entry or release from the host cell. Some plants also interacted with the viral RNA replication or by reducing proinflammatory cytokines. Ethanol was mostly used for extraction. Among all the plants Theobroma cacao, Capparis Sinaica Veil, Androgarphis paniculate, Thallasodendron cillatum, Sinularia candidula, Larcifomes officinalis, Lenzites betulina, Datronia molis, Trametes gibbose exhibited their activity with least concentration (below 10 μg/ml). The dockings results showed that some natural compounds (5,7- dimethoxyflavone, Aloe emodin, Anthocyanins, Quercetin, Hemanthamine, Lyocrine, Terpenoid EA showed satisfactory binding affinity and binding specificity with viral neuraminidase compared to the synthetic drugs. CONCLUSION: This review clusters up to date information of effective herbal plants to bolster future influenza treatment research in chickens. The in-silico analysis also suggests some potential targets for future drug development but these require more clinical analysis. Elsevier 2023-03-10 /pmc/articles/PMC10011005/ /pubmed/36925514 http://dx.doi.org/10.1016/j.heliyon.2023.e14386 Text en © 2023 Published by Elsevier Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Article Dutta, Ashit Kumar Gazi, Md Shamim Uddin, Shaikh Jamal A systemic review on medicinal plants and their bioactive constituents against avian influenza and further confirmation through in-silico analysis |
title | A systemic review on medicinal plants and their bioactive constituents against avian influenza and further confirmation through in-silico analysis |
title_full | A systemic review on medicinal plants and their bioactive constituents against avian influenza and further confirmation through in-silico analysis |
title_fullStr | A systemic review on medicinal plants and their bioactive constituents against avian influenza and further confirmation through in-silico analysis |
title_full_unstemmed | A systemic review on medicinal plants and their bioactive constituents against avian influenza and further confirmation through in-silico analysis |
title_short | A systemic review on medicinal plants and their bioactive constituents against avian influenza and further confirmation through in-silico analysis |
title_sort | systemic review on medicinal plants and their bioactive constituents against avian influenza and further confirmation through in-silico analysis |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10011005/ https://www.ncbi.nlm.nih.gov/pubmed/36925514 http://dx.doi.org/10.1016/j.heliyon.2023.e14386 |
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