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Mitochondrial respiration reduces exposure of the nucleus to oxygen

The endosymbiotic theory posits that ancient eukaryotic cells engulfed O(2)-consuming prokaryotes, which protected them against O(2) toxicity. Previous studies have shown that cells lacking cytochrome c oxidase (COX), required for respiration, have increased DNA damage and reduced proliferation, whi...

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Detalles Bibliográficos
Autores principales: Mori, Mateus Prates, Penjweini, Rozhin, Ma, Jin, Alspaugh, Greg, Andreoni, Alessio, Kim, Young-Chae, Wang, Ping-yuan, Knutson, Jay R., Hwang, Paul M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10011062/
https://www.ncbi.nlm.nih.gov/pubmed/36796514
http://dx.doi.org/10.1016/j.jbc.2023.103018