Chemotherapy-induced cavitating Wilms' tumor pulmonary metastasis: Active disease or scarring? A case report and literature review

The second most common abdominal tumor in children is Wilms’ tumor, and the lung is where it most often metastasizes. The typical metastases are multiple, peripherally located, round, and variable-sized nodules. Atypical patterns are also possible and may create diagnostic challenges, especially in...

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Autores principales: Zarfati, Angelo, Martucci, Cristina, Crocoli, Alessandro, Serra, Annalisa, Persano, Giorgio, Inserra, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pediatrics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10011097/
https://www.ncbi.nlm.nih.gov/pubmed/36925669
http://dx.doi.org/10.3389/fped.2023.1083168
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author Zarfati, Angelo
Martucci, Cristina
Crocoli, Alessandro
Serra, Annalisa
Persano, Giorgio
Inserra, Alessandro
author_facet Zarfati, Angelo
Martucci, Cristina
Crocoli, Alessandro
Serra, Annalisa
Persano, Giorgio
Inserra, Alessandro
author_sort Zarfati, Angelo
collection PubMed
description The second most common abdominal tumor in children is Wilms’ tumor, and the lung is where it most often metastasizes. The typical metastases are multiple, peripherally located, round, and variable-sized nodules. Atypical patterns are also possible and may create diagnostic challenges, especially in patients treated with chemotherapy. Among these, cavitating metastases are an anecdotal type of atypical secondary lung lesions. Here, we report a case of a chemotherapy-induced cavitating Wilms' tumor pulmonary metastasis discovered during the follow-up for an anaplastic nephroblastoma in a 6-year-old girl. Furthermore, we conducted a review of the existing literature on this exceedingly rare radiological pattern to establish its best management.
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spelling pubmed-100110972023-03-15 Chemotherapy-induced cavitating Wilms' tumor pulmonary metastasis: Active disease or scarring? A case report and literature review Zarfati, Angelo Martucci, Cristina Crocoli, Alessandro Serra, Annalisa Persano, Giorgio Inserra, Alessandro Front Pediatr Pediatrics The second most common abdominal tumor in children is Wilms’ tumor, and the lung is where it most often metastasizes. The typical metastases are multiple, peripherally located, round, and variable-sized nodules. Atypical patterns are also possible and may create diagnostic challenges, especially in patients treated with chemotherapy. Among these, cavitating metastases are an anecdotal type of atypical secondary lung lesions. Here, we report a case of a chemotherapy-induced cavitating Wilms' tumor pulmonary metastasis discovered during the follow-up for an anaplastic nephroblastoma in a 6-year-old girl. Furthermore, we conducted a review of the existing literature on this exceedingly rare radiological pattern to establish its best management. Frontiers Media S.A. 2023-02-28 /pmc/articles/PMC10011097/ /pubmed/36925669 http://dx.doi.org/10.3389/fped.2023.1083168 Text en © 2023 Zarfati, Martucci, Crocoli, Serra, Persano and Inserra. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Zarfati, Angelo
Martucci, Cristina
Crocoli, Alessandro
Serra, Annalisa
Persano, Giorgio
Inserra, Alessandro
Chemotherapy-induced cavitating Wilms' tumor pulmonary metastasis: Active disease or scarring? A case report and literature review
title Chemotherapy-induced cavitating Wilms' tumor pulmonary metastasis: Active disease or scarring? A case report and literature review
title_full Chemotherapy-induced cavitating Wilms' tumor pulmonary metastasis: Active disease or scarring? A case report and literature review
title_fullStr Chemotherapy-induced cavitating Wilms' tumor pulmonary metastasis: Active disease or scarring? A case report and literature review
title_full_unstemmed Chemotherapy-induced cavitating Wilms' tumor pulmonary metastasis: Active disease or scarring? A case report and literature review
title_short Chemotherapy-induced cavitating Wilms' tumor pulmonary metastasis: Active disease or scarring? A case report and literature review
title_sort chemotherapy-induced cavitating wilms' tumor pulmonary metastasis: active disease or scarring? a case report and literature review
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10011097/
https://www.ncbi.nlm.nih.gov/pubmed/36925669
http://dx.doi.org/10.3389/fped.2023.1083168
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