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Consequences of spinal cord injury on the sympathetic nervous system
Spinal cord injury (SCI) damages multiple structures at the lesion site, including ascending, descending, and propriospinal axons; interrupting the conduction of information up and down the spinal cord. Additionally, axons associated with the autonomic nervous system that control involuntary physiol...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10011113/ https://www.ncbi.nlm.nih.gov/pubmed/36925966 http://dx.doi.org/10.3389/fncel.2023.999253 |
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author | Wulf, Mariah J. Tom, Veronica J. |
author_facet | Wulf, Mariah J. Tom, Veronica J. |
author_sort | Wulf, Mariah J. |
collection | PubMed |
description | Spinal cord injury (SCI) damages multiple structures at the lesion site, including ascending, descending, and propriospinal axons; interrupting the conduction of information up and down the spinal cord. Additionally, axons associated with the autonomic nervous system that control involuntary physiological functions course through the spinal cord. Moreover, sympathetic, and parasympathetic preganglionic neurons reside in the spinal cord. Thus, depending on the level of an SCI, autonomic function can be greatly impacted by the trauma resulting in dysfunction of various organs. For example, SCI can lead to dysregulation of a variety of organs, such as the pineal gland, the heart and vasculature, lungs, spleen, kidneys, and bladder. Indeed, it is becoming more apparent that many disorders that negatively affect quality-of-life for SCI individuals have a basis in dysregulation of the sympathetic nervous system. Here, we will review how SCI impacts the sympathetic nervous system and how that negatively impacts target organs that receive sympathetic innervation. A deeper understanding of this may offer potential therapeutic insight into how to improve health and quality-of-life for those living with SCI. |
format | Online Article Text |
id | pubmed-10011113 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-100111132023-03-15 Consequences of spinal cord injury on the sympathetic nervous system Wulf, Mariah J. Tom, Veronica J. Front Cell Neurosci Neuroscience Spinal cord injury (SCI) damages multiple structures at the lesion site, including ascending, descending, and propriospinal axons; interrupting the conduction of information up and down the spinal cord. Additionally, axons associated with the autonomic nervous system that control involuntary physiological functions course through the spinal cord. Moreover, sympathetic, and parasympathetic preganglionic neurons reside in the spinal cord. Thus, depending on the level of an SCI, autonomic function can be greatly impacted by the trauma resulting in dysfunction of various organs. For example, SCI can lead to dysregulation of a variety of organs, such as the pineal gland, the heart and vasculature, lungs, spleen, kidneys, and bladder. Indeed, it is becoming more apparent that many disorders that negatively affect quality-of-life for SCI individuals have a basis in dysregulation of the sympathetic nervous system. Here, we will review how SCI impacts the sympathetic nervous system and how that negatively impacts target organs that receive sympathetic innervation. A deeper understanding of this may offer potential therapeutic insight into how to improve health and quality-of-life for those living with SCI. Frontiers Media S.A. 2023-02-28 /pmc/articles/PMC10011113/ /pubmed/36925966 http://dx.doi.org/10.3389/fncel.2023.999253 Text en Copyright © 2023 Wulf and Tom. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Wulf, Mariah J. Tom, Veronica J. Consequences of spinal cord injury on the sympathetic nervous system |
title | Consequences of spinal cord injury on the sympathetic nervous system |
title_full | Consequences of spinal cord injury on the sympathetic nervous system |
title_fullStr | Consequences of spinal cord injury on the sympathetic nervous system |
title_full_unstemmed | Consequences of spinal cord injury on the sympathetic nervous system |
title_short | Consequences of spinal cord injury on the sympathetic nervous system |
title_sort | consequences of spinal cord injury on the sympathetic nervous system |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10011113/ https://www.ncbi.nlm.nih.gov/pubmed/36925966 http://dx.doi.org/10.3389/fncel.2023.999253 |
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