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Blood biomarkers of secondary outcomes following concussion: A systematic review

INTRODUCTION: Blood biomarkers have been identified as an alternative tool for predicting secondary outcomes following concussion. This systematic review aimed to summarize the literature on blood biomarkers of secondary outcomes following concussion in both pediatric and adult cohorts. METHODS: A l...

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Autores principales: Swaney, Ella E. K., Cai, Tengyi, Seal, Marc L., Ignjatovic, Vera
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10011122/
https://www.ncbi.nlm.nih.gov/pubmed/36925940
http://dx.doi.org/10.3389/fneur.2023.989974
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author Swaney, Ella E. K.
Cai, Tengyi
Seal, Marc L.
Ignjatovic, Vera
author_facet Swaney, Ella E. K.
Cai, Tengyi
Seal, Marc L.
Ignjatovic, Vera
author_sort Swaney, Ella E. K.
collection PubMed
description INTRODUCTION: Blood biomarkers have been identified as an alternative tool for predicting secondary outcomes following concussion. This systematic review aimed to summarize the literature on blood biomarkers of secondary outcomes following concussion in both pediatric and adult cohorts. METHODS: A literature search of Embase, Medline and PubMed was conducted. Two reviewers independently assessed retrieved studies to determine inclusion in systematic review synthesis. RESULTS: A total of 1771 unique studies were retrieved, 58 of which were included in the final synthesis. S100B, GFAP and tau were identified as being associated with secondary outcomes following concussion. Seventeen percent of studies were performed in a solely pediatric setting. CONCLUSIONS: Validation of biomarkers associated with secondary outcomes following concussion have been largely limited by heterogeneous study cohorts and definitions of concussion and mTBI, presenting a hurdle for translation of these markers into clinical practice. Additionally, there was an underrepresentation of studies which investigated pediatric cohorts. Adult markers are not appropriate for children, therefore pediatric specific markers of secondary outcomes following concussion present the biggest gap in this field.
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spelling pubmed-100111222023-03-15 Blood biomarkers of secondary outcomes following concussion: A systematic review Swaney, Ella E. K. Cai, Tengyi Seal, Marc L. Ignjatovic, Vera Front Neurol Neurology INTRODUCTION: Blood biomarkers have been identified as an alternative tool for predicting secondary outcomes following concussion. This systematic review aimed to summarize the literature on blood biomarkers of secondary outcomes following concussion in both pediatric and adult cohorts. METHODS: A literature search of Embase, Medline and PubMed was conducted. Two reviewers independently assessed retrieved studies to determine inclusion in systematic review synthesis. RESULTS: A total of 1771 unique studies were retrieved, 58 of which were included in the final synthesis. S100B, GFAP and tau were identified as being associated with secondary outcomes following concussion. Seventeen percent of studies were performed in a solely pediatric setting. CONCLUSIONS: Validation of biomarkers associated with secondary outcomes following concussion have been largely limited by heterogeneous study cohorts and definitions of concussion and mTBI, presenting a hurdle for translation of these markers into clinical practice. Additionally, there was an underrepresentation of studies which investigated pediatric cohorts. Adult markers are not appropriate for children, therefore pediatric specific markers of secondary outcomes following concussion present the biggest gap in this field. Frontiers Media S.A. 2023-02-28 /pmc/articles/PMC10011122/ /pubmed/36925940 http://dx.doi.org/10.3389/fneur.2023.989974 Text en Copyright © 2023 Swaney, Cai, Seal and Ignjatovic. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Swaney, Ella E. K.
Cai, Tengyi
Seal, Marc L.
Ignjatovic, Vera
Blood biomarkers of secondary outcomes following concussion: A systematic review
title Blood biomarkers of secondary outcomes following concussion: A systematic review
title_full Blood biomarkers of secondary outcomes following concussion: A systematic review
title_fullStr Blood biomarkers of secondary outcomes following concussion: A systematic review
title_full_unstemmed Blood biomarkers of secondary outcomes following concussion: A systematic review
title_short Blood biomarkers of secondary outcomes following concussion: A systematic review
title_sort blood biomarkers of secondary outcomes following concussion: a systematic review
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10011122/
https://www.ncbi.nlm.nih.gov/pubmed/36925940
http://dx.doi.org/10.3389/fneur.2023.989974
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