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Assessment of normal myelination in infants and young children using the T1w/T2w mapping technique

BACKGROUND: White matter myelination is a crucial process of CNS maturation. The purpose of this study was to validate the T1w/T2w mapping technique for brain myelination assessment in infants and young children. METHODS: Ninety-four patients (0–23 months of age) without structural abnormalities on...

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Autores principales: Filimonova, Elena, Amelina, Evgenia, Sazonova, Aleksandra, Zaitsev, Boris, Rzaev, Jamil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10011126/
https://www.ncbi.nlm.nih.gov/pubmed/36925743
http://dx.doi.org/10.3389/fnins.2023.1102691
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author Filimonova, Elena
Amelina, Evgenia
Sazonova, Aleksandra
Zaitsev, Boris
Rzaev, Jamil
author_facet Filimonova, Elena
Amelina, Evgenia
Sazonova, Aleksandra
Zaitsev, Boris
Rzaev, Jamil
author_sort Filimonova, Elena
collection PubMed
description BACKGROUND: White matter myelination is a crucial process of CNS maturation. The purpose of this study was to validate the T1w/T2w mapping technique for brain myelination assessment in infants and young children. METHODS: Ninety-four patients (0–23 months of age) without structural abnormalities on brain MRI were evaluated by using the T1w/T2w mapping method. The T1w/T2w signal intensity ratio, which reflects white matter integrity and the degree of myelination, was calculated in various brain regions. We performed a Pearson correlation analysis, a LOESS regression analysis, and a 2(nd) order polynomial regression analysis to describe the relationships between the regional metrics and the age of the patients (in months). RESULTS: T1w/T2w ratio values rapidly increased in the first 6–9 months of life and then slowed thereafter. The T1w/T2w mapping technique emphasized the contrast between myelinated and less myelinated structures in all age groups, which resulted in better visualization. There were strong positive correlations between the T1w/T2w ratio values from the majority of white matter ROIs and the subjects’ age (R = 0.7–0.9, p < 0.001). Within all of the analyzed regions, there were non-linear relationships between age and T1/T2 ratio values that varied by anatomical and functional location. Regions such as the splenium and the genu of the corpus callosum showed the highest R(2) values, thus indicating less scattering of data and a better fit to the model. CONCLUSION: The T1w/T2w mapping technique may enhance our diagnostic ability to assess myelination patterns in the brains of infants and young children.
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spelling pubmed-100111262023-03-15 Assessment of normal myelination in infants and young children using the T1w/T2w mapping technique Filimonova, Elena Amelina, Evgenia Sazonova, Aleksandra Zaitsev, Boris Rzaev, Jamil Front Neurosci Neuroscience BACKGROUND: White matter myelination is a crucial process of CNS maturation. The purpose of this study was to validate the T1w/T2w mapping technique for brain myelination assessment in infants and young children. METHODS: Ninety-four patients (0–23 months of age) without structural abnormalities on brain MRI were evaluated by using the T1w/T2w mapping method. The T1w/T2w signal intensity ratio, which reflects white matter integrity and the degree of myelination, was calculated in various brain regions. We performed a Pearson correlation analysis, a LOESS regression analysis, and a 2(nd) order polynomial regression analysis to describe the relationships between the regional metrics and the age of the patients (in months). RESULTS: T1w/T2w ratio values rapidly increased in the first 6–9 months of life and then slowed thereafter. The T1w/T2w mapping technique emphasized the contrast between myelinated and less myelinated structures in all age groups, which resulted in better visualization. There were strong positive correlations between the T1w/T2w ratio values from the majority of white matter ROIs and the subjects’ age (R = 0.7–0.9, p < 0.001). Within all of the analyzed regions, there were non-linear relationships between age and T1/T2 ratio values that varied by anatomical and functional location. Regions such as the splenium and the genu of the corpus callosum showed the highest R(2) values, thus indicating less scattering of data and a better fit to the model. CONCLUSION: The T1w/T2w mapping technique may enhance our diagnostic ability to assess myelination patterns in the brains of infants and young children. Frontiers Media S.A. 2023-02-28 /pmc/articles/PMC10011126/ /pubmed/36925743 http://dx.doi.org/10.3389/fnins.2023.1102691 Text en Copyright © 2023 Filimonova, Amelina, Sazonova, Zaitsev and Rzaev. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Filimonova, Elena
Amelina, Evgenia
Sazonova, Aleksandra
Zaitsev, Boris
Rzaev, Jamil
Assessment of normal myelination in infants and young children using the T1w/T2w mapping technique
title Assessment of normal myelination in infants and young children using the T1w/T2w mapping technique
title_full Assessment of normal myelination in infants and young children using the T1w/T2w mapping technique
title_fullStr Assessment of normal myelination in infants and young children using the T1w/T2w mapping technique
title_full_unstemmed Assessment of normal myelination in infants and young children using the T1w/T2w mapping technique
title_short Assessment of normal myelination in infants and young children using the T1w/T2w mapping technique
title_sort assessment of normal myelination in infants and young children using the t1w/t2w mapping technique
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10011126/
https://www.ncbi.nlm.nih.gov/pubmed/36925743
http://dx.doi.org/10.3389/fnins.2023.1102691
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