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Immune selection determines tumor antigenicity and influences response to checkpoint inhibitors

In cancer, evolutionary forces select for clones that evade the immune system. Here we analyzed >10,000 primary tumors and 356 immune-checkpoint-treated metastases using immune dN/dS, the ratio of nonsynonymous to synonymous mutations in the immunopeptidome, to measure immune selection in cohorts...

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Detalles Bibliográficos
Autores principales:	Zapata, Luis, Caravagna, Giulio, Williams, Marc J., Lakatos, Eszter, AbdulJabbar, Khalid, Werner, Benjamin, Chowell, Diego, James, Chela, Gourmet, Lucie, Milite, Salvatore, Acar, Ahmet, Riaz, Nadeem, Chan, Timothy A., Graham, Trevor A., Sottoriva, Andrea
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group US 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10011129/ https://www.ncbi.nlm.nih.gov/pubmed/36894710 http://dx.doi.org/10.1038/s41588-023-01313-1

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