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Effect of endodontic treatment on clinical outcome in type 2 diabetic patients with apical periodontitis

BACKGROUND: Previous research has demonstrated that poor controlled diabetic showed higher prevalence of AP compared to well-controlled patients and endodontic treatment may improve metabolic control of patients with diabetes. The purpose of this trial was to clinically assess the effects of endodon...

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Autores principales: Wang, Shengming, Wang, Xiaoqing, Bai, Feng, Shi, Xinlian, Zhou, Tingting, Li, Fangfang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10011187/
https://www.ncbi.nlm.nih.gov/pubmed/36925517
http://dx.doi.org/10.1016/j.heliyon.2023.e13914
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author Wang, Shengming
Wang, Xiaoqing
Bai, Feng
Shi, Xinlian
Zhou, Tingting
Li, Fangfang
author_facet Wang, Shengming
Wang, Xiaoqing
Bai, Feng
Shi, Xinlian
Zhou, Tingting
Li, Fangfang
author_sort Wang, Shengming
collection PubMed
description BACKGROUND: Previous research has demonstrated that poor controlled diabetic showed higher prevalence of AP compared to well-controlled patients and endodontic treatment may improve metabolic control of patients with diabetes. The purpose of this trial was to clinically assess the effects of endodontic treatment on glycemic control in patients with type 2 diabetes mellitus (T2DM) and apical periodontitis (AP). STUDY DESIGN: For present trial, AP + T2DM with patients insulin injection (Group1, G1,n = 65), AP + T2DM patients with hypoglycaemic agents (Group2, G2, n = 82), and AP patients without DM (Group3, G3, n = 86) were enrolled. After demographic characteristics and clinical examination were achieved, root canal treatment (RCT) was performed for each patient. Subjects were followed up at 2-week, 3- and 6-month. At each visit, blood samples were taken and clinical laboratory studies were performed. At 6-month follow-up, Periapical Index (PAI) score was used to assess the periapical status. RESULTS: A total of 237 subjects who met the including criteria were allocated in three groups and 223 subjects (94.1%) completed the treatments and the follow-up assessments. After treatment, taking PAI into consideration, both groups showed significant improvement of AP in each group (P < 0.05). Patients in G3 had a continued significant lower concentration of fasting plasma glucose (FPG) levels at follow-up (P < 0.05). A continued reduction of hemoglobin glycation (HbA1c) was observed in most of time points (P < 0.05). Throughout the trial, there are also significant changes in inflammatory factors in short-term. CONCLUSION: Endodontic therapy improved AP healing, glycemic control and systemic inflammation in patients with T2DM and/or AP in each group. However, a continued reduction in inflammatory factors and decreasing of HbA1c in short-term could not be observed in this trial.
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spelling pubmed-100111872023-03-15 Effect of endodontic treatment on clinical outcome in type 2 diabetic patients with apical periodontitis Wang, Shengming Wang, Xiaoqing Bai, Feng Shi, Xinlian Zhou, Tingting Li, Fangfang Heliyon Research Article BACKGROUND: Previous research has demonstrated that poor controlled diabetic showed higher prevalence of AP compared to well-controlled patients and endodontic treatment may improve metabolic control of patients with diabetes. The purpose of this trial was to clinically assess the effects of endodontic treatment on glycemic control in patients with type 2 diabetes mellitus (T2DM) and apical periodontitis (AP). STUDY DESIGN: For present trial, AP + T2DM with patients insulin injection (Group1, G1,n = 65), AP + T2DM patients with hypoglycaemic agents (Group2, G2, n = 82), and AP patients without DM (Group3, G3, n = 86) were enrolled. After demographic characteristics and clinical examination were achieved, root canal treatment (RCT) was performed for each patient. Subjects were followed up at 2-week, 3- and 6-month. At each visit, blood samples were taken and clinical laboratory studies were performed. At 6-month follow-up, Periapical Index (PAI) score was used to assess the periapical status. RESULTS: A total of 237 subjects who met the including criteria were allocated in three groups and 223 subjects (94.1%) completed the treatments and the follow-up assessments. After treatment, taking PAI into consideration, both groups showed significant improvement of AP in each group (P < 0.05). Patients in G3 had a continued significant lower concentration of fasting plasma glucose (FPG) levels at follow-up (P < 0.05). A continued reduction of hemoglobin glycation (HbA1c) was observed in most of time points (P < 0.05). Throughout the trial, there are also significant changes in inflammatory factors in short-term. CONCLUSION: Endodontic therapy improved AP healing, glycemic control and systemic inflammation in patients with T2DM and/or AP in each group. However, a continued reduction in inflammatory factors and decreasing of HbA1c in short-term could not be observed in this trial. Elsevier 2023-02-22 /pmc/articles/PMC10011187/ /pubmed/36925517 http://dx.doi.org/10.1016/j.heliyon.2023.e13914 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Wang, Shengming
Wang, Xiaoqing
Bai, Feng
Shi, Xinlian
Zhou, Tingting
Li, Fangfang
Effect of endodontic treatment on clinical outcome in type 2 diabetic patients with apical periodontitis
title Effect of endodontic treatment on clinical outcome in type 2 diabetic patients with apical periodontitis
title_full Effect of endodontic treatment on clinical outcome in type 2 diabetic patients with apical periodontitis
title_fullStr Effect of endodontic treatment on clinical outcome in type 2 diabetic patients with apical periodontitis
title_full_unstemmed Effect of endodontic treatment on clinical outcome in type 2 diabetic patients with apical periodontitis
title_short Effect of endodontic treatment on clinical outcome in type 2 diabetic patients with apical periodontitis
title_sort effect of endodontic treatment on clinical outcome in type 2 diabetic patients with apical periodontitis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10011187/
https://www.ncbi.nlm.nih.gov/pubmed/36925517
http://dx.doi.org/10.1016/j.heliyon.2023.e13914
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