Safety and Efficacy of Double Lamellar Keratoplasty for Corneal Perforation

INTRODUCTION: To assess the outcomes of double lamellar keratoplasty in the treatment of corneal perforation secondary to various keratopathies. METHODS: In this prospective non-comparative interventional case series, 15 eyes from 15 consecutive patients with corneal perforation were chosen to undergo double lamellar keratoplasty, which is characterized by two layers of lamellar grafting in the perforated area. The posterior graft was separated from a relatively healthy and thin lamellar graft of the recipient, and the anterior graft was transplanted from the donor lamellar cornea. Preoperative characteristics and postoperative examination and relevant complications throughout the study were recorded. RESULTS: Nine men and six women with an average age of 50.73 ± 19.89 (range, 9–84) years were enrolled. The median follow-up period was 18 (range, 12–30) months. In all postoperative patients, the integrity of the eyeball was successfully rebuilt, and the anterior chambers were formed without aqueous leakage. At the last visit, best-corrected visual acuity improved in 14/15 patients (93.3%). Slit-lamp microscopy showed that all treated eyes remained fully transparent. Anterior segment optical coherence tomography revealed that the double-layer structure of the treated cornea was clear in the early postoperative stage. In vivo confocal microscopy revealed intact epithelial cells, sub-basal nerves, and clear keratocytes in the transplanted cornea. No immune rejection or recurrence was detected during the follow-up period. CONCLUSIONS: Double lamellar keratoplasty presents a new therapeutic option for patients undergoing corneal perforation, and it provides improvement in visual acuity and reduces the risk of postoperative adverse events. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s40123-023-00676-2.